Biophysik

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Astronauts will inevitably be exposed to low doses of ionizing radiation during future space missions, such as the transit to Mars. The effects on the brain and cognitive risks for astronauts are only partially understood, in part due to technical limitations in realistically reproducing the cosmic radiation composition [...]

Clustered DNA damage as one of the hallmarks of ionizing radiation, poses a great risk on the genomic integrity. High frequencies of clustered DNA damage induced by ionizing radiation increase the overall cancer risk. [...]

Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models derived from in vitro studies have proposed distinct nucleosome chain geometries, the organization of chromatin within the crowded cell nucleus remains elusive. [...]

Space radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. [...]