% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Fournier:186295,
      author       = {Fournier, C. and Becker, D. and Winter, M. and Barberet, P.
                      and Heiss, M. and Fischer, B. and Topsch, J. and
                      Taucher-Scholz, G.},
      title        = {{C}ell cycle-related bystander responses are not increased
                      with {LET} after heavy-ion irradiation.},
      journal      = {Radiation research},
      volume       = {167},
      number       = {2},
      issn         = {0033-7587},
      address      = {Great Falls, Va.},
      publisher    = {Radiation Research Society},
      reportid     = {GSI-2016-00793},
      pages        = {-},
      year         = {2007},
      abstract     = {Evidence has accumulated that irradiated cells affect their
                      unirradiated neighbors, so that they in turn display
                      cellular responses typically associated with direct
                      radiation exposure. These responses are generally known as
                      bystander effects. In this study, cell cycle-related
                      bystander responses were investigated in three strains of
                      human fibroblasts after exposure to densely ionizing
                      radiation. Varying the linear energy transfer (LET) from 11
                      to 15,000 keV microm(-1) allowed a study of the impact of
                      the complexity of DNA damage in the inducing cells on the
                      responses of bystander cells. Using both broad-beam and
                      microbeam irradiation, transient bystander responses were
                      obtained for the induction of CDKN1A (p21). The latter was
                      also observed when the transmission of bystander signals was
                      limited to soluble factors. Targeted irradiation of single
                      cells in confluent cell monolayers revealed no correlation
                      between the amount of CDKN1A protein in the bystander cells
                      and the radial distance to the targeted cells. In line with
                      the induction of CDKN1A in bystander cells after irradiation
                      with different LETs, a transient delay in the first G1 phase
                      after irradiation of G0/G1 cells was observed. However, the
                      CDKN1A induction revealed no significant effect on premature
                      terminal differentiation considered to underlie fibrosis in
                      irradiated tissue. Thus the unchanged differentiation
                      pattern in bystander cells does not indicate pronounced,
                      long-lasting effects.},
      keywords     = {CDKN1A protein, human (NLM Chemicals) / Cyclin-Dependent
                      Kinase Inhibitor p21 (NLM Chemicals) / Ions (NLM Chemicals)},
      cin          = {BIO},
      ddc          = {610},
      cid          = {I:(DE-Ds200)BIO-20160831OR354},
      pnm          = {899 - ohne Topic (POF3-899) / 310 - Krebsforschung
                      (POF1-300)},
      pid          = {G:(DE-HGF)POF3-899 / G:(DE-HGF)POF1-310},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17390727},
      url          = {https://repository.gsi.de/record/186295},
}