000186296 001__ 186296
000186296 005__ 20230317124310.0
000186296 0247_ $$2doi$$a10.1016/j.radonc.2007.04.022
000186296 0247_ $$2pmid$$apmid:17499869
000186296 0247_ $$2ISSN$$a0167-8140
000186296 0247_ $$2ISSN$$a1879-0887
000186296 0247_ $$2WOS$$aWOS:000248070300009
000186296 037__ $$aGSI-2016-00794
000186296 041__ $$aeng
000186296 082__ $$a610
000186296 1001_ $$0P:(DE-Ds200)OR0311$$aFournier, Claudia$$b0$$ugsi
000186296 245__ $$aInterrelation amongst differentiation, senescence and genetic instability in long-term cultures of fibroblasts exposed to different radiation qualities.
000186296 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2007
000186296 3367_ $$00$$2EndNote$$aJournal Article
000186296 3367_ $$2DRIVER$$aarticle
000186296 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1464104637_16055
000186296 3367_ $$2BibTeX$$aARTICLE
000186296 520__ $$aThe goal of the present study was to investigate aging and genetic instability in the progeny of human fibroblasts exposed to X-rays and carbon ions.Following irradiation, cells were regularly subcultured until senescence. At selected time-points BrdU-labelling index, expression of cell cycle related proteins, cell differentiation pattern and chromosome aberrations were assessed.After exposure, an immediate cell cycle arrest occurred followed by a period of a few weeks where premature differentiation and senescence were observed. In all cultures cycling cells expressing low levels of cell cycle inhibiting proteins were present and finally dominated the populations. About 5months after exposure, the cellular and molecular changes attributed to differentiation and senescence reappeared and persisted. Concurrently, genetic instability was observed, but the aberration yields and types differed between repeated experiments. The descendants of cells exposed to carbon ions did not senesce earlier and displayed a similar rate of genetic instability as the X-ray progeny. For high doses an impaired cell cycle regulation and extended life span was observed, but finally cell proliferation ceased in all populations.The descendants of irradiated fibroblasts undergo stepwise senescence and differentiation. Genetic instability is frequent and an extension of the life span may occur.
000186296 536__ $$0G:(DE-HGF)POF3-899$$a899 - ohne Topic (POF3-899)$$cPOF3-899$$fPOF III$$x0
000186296 536__ $$0G:(DE-HGF)POF1-310$$a310 - Krebsforschung (POF1-300)$$cPOF1-300$$fPOF I$$x1
000186296 588__ $$aDataset connected to CrossRef, PubMed,
000186296 650_7 $$2NLM Chemicals$$aCell Cycle Proteins
000186296 650_7 $$2NLM Chemicals$$aIons
000186296 650_7 $$07440-44-0$$2NLM Chemicals$$aCarbon
000186296 7001_ $$0P:(DE-HGF)0$$aWinter, Marcus$$b1
000186296 7001_ $$0P:(DE-HGF)0$$aZahnreich, Sebastian$$b2
000186296 7001_ $$0P:(DE-HGF)0$$aNasonova, Elena$$b3
000186296 7001_ $$0P:(DE-HGF)0$$aMelnikova, Larissa$$b4
000186296 7001_ $$0P:(DE-Ds200)OR1036$$aRitter, Sylvia$$b5$$ugsi
000186296 773__ $$0PERI:(DE-600)1500707-8$$a10.1016/j.radonc.2007.04.022$$gVol. 83, no. 3, p. 277 - 282$$n3$$p277 - 282$$tRadiotherapy and oncology$$v83$$x0167-8140$$y2007
000186296 909CO $$ooai:repository.gsi.de:186296$$pVDB
000186296 9101_ $$0I:(DE-Ds200)20121206GSI$$6P:(DE-Ds200)OR0311$$aGSI Helmholtzzentrum für Schwerionenforschung GmbH$$b0$$kGSI
000186296 9101_ $$0I:(DE-Ds200)20121206GSI$$6P:(DE-Ds200)OR1036$$aGSI Helmholtzzentrum für Schwerionenforschung GmbH$$b5$$kGSI
000186296 9131_ $$0G:(DE-HGF)POF3-899$$1G:(DE-HGF)POF3-890$$2G:(DE-HGF)POF3-800$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000186296 9131_ $$0G:(DE-HGF)POF1-300$$1G:(DE-HGF)POF1-310$$2G:(DE-HGF)POF1-300$$3G:(DE-HGF)POF1$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF1-310$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vGesundheit$$x1
000186296 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bRADIOTHER ONCOL : 2013
000186296 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000186296 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000186296 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000186296 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000186296 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000186296 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000186296 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000186296 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000186296 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000186296 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000186296 920__ $$lyes
000186296 9201_ $$0I:(DE-Ds200)BIO-20160831OR354$$kBIO$$lBiophysik$$x0
000186296 980__ $$ajournal
000186296 980__ $$aVDB
000186296 980__ $$aI:(DE-Ds200)20110831OR021
000186296 980__ $$aI:(DE-Ds200)BIO-20160831OR354
000186296 980__ $$aUNRESTRICTED