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@ARTICLE{Fournier:186296,
      author       = {Fournier, Claudia and Winter, Marcus and Zahnreich,
                      Sebastian and Nasonova, Elena and Melnikova, Larissa and
                      Ritter, Sylvia},
      title        = {{I}nterrelation amongst differentiation, senescence and
                      genetic instability in long-term cultures of fibroblasts
                      exposed to different radiation qualities.},
      journal      = {Radiotherapy and oncology},
      volume       = {83},
      number       = {3},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {GSI-2016-00794},
      pages        = {277 - 282},
      year         = {2007},
      abstract     = {The goal of the present study was to investigate aging and
                      genetic instability in the progeny of human fibroblasts
                      exposed to X-rays and carbon ions.Following irradiation,
                      cells were regularly subcultured until senescence. At
                      selected time-points BrdU-labelling index, expression of
                      cell cycle related proteins, cell differentiation pattern
                      and chromosome aberrations were assessed.After exposure, an
                      immediate cell cycle arrest occurred followed by a period of
                      a few weeks where premature differentiation and senescence
                      were observed. In all cultures cycling cells expressing low
                      levels of cell cycle inhibiting proteins were present and
                      finally dominated the populations. About 5months after
                      exposure, the cellular and molecular changes attributed to
                      differentiation and senescence reappeared and persisted.
                      Concurrently, genetic instability was observed, but the
                      aberration yields and types differed between repeated
                      experiments. The descendants of cells exposed to carbon ions
                      did not senesce earlier and displayed a similar rate of
                      genetic instability as the X-ray progeny. For high doses an
                      impaired cell cycle regulation and extended life span was
                      observed, but finally cell proliferation ceased in all
                      populations.The descendants of irradiated fibroblasts
                      undergo stepwise senescence and differentiation. Genetic
                      instability is frequent and an extension of the life span
                      may occur.},
      keywords     = {Cell Cycle Proteins (NLM Chemicals) / Ions (NLM Chemicals)
                      / Carbon (NLM Chemicals)},
      cin          = {BIO},
      ddc          = {610},
      cid          = {I:(DE-Ds200)BIO-20160831OR354},
      pnm          = {899 - ohne Topic (POF3-899) / 310 - Krebsforschung
                      (POF1-300)},
      pid          = {G:(DE-HGF)POF3-899 / G:(DE-HGF)POF1-310},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17499869},
      UT           = {WOS:000248070300009},
      doi          = {10.1016/j.radonc.2007.04.022},
      url          = {https://repository.gsi.de/record/186296},
}