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@ARTICLE{Goetze:186297,
      author       = {Goetze, K. and Scholz, M. and Taucher-Scholz, G. and
                      Mueller-Klieser, W.},
      title        = {{T}he impact of conventional and heavy ion irradiation on
                      tumor cell migration in vitro.},
      journal      = {International journal of radiation biology},
      volume       = {83},
      number       = {11-12},
      issn         = {1362-3095},
      address      = {Abingdon},
      publisher    = {Informa Healthcare36371},
      reportid     = {GSI-2016-00795},
      pages        = {889 - 896},
      year         = {2007},
      abstract     = {The influence of X-ray and (12)C heavy ion irradiation on
                      tumor cell migration and of beta(3) and beta(1) integrin
                      expression was investigated.Two different tumor cell lines
                      (U87 glioma and HCT116 colon carcinoma cells) were
                      irradiated with 1, 3, or 10 Gy X-rays or (12)C heavy ions.
                      24 h after irradiation a standardized Boyden Chamber assay
                      for migration analysis was performed and cells were lysed
                      for Western blotting.Radiation-induced influences were cell
                      line- and radiation type-dependent. X-rays decreased HCT116
                      migration at higher doses and appear to increase U87
                      migration after 3 Gy. Heavy ions decreased migration of both
                      cell lines dose-dependently. A trend of increased beta(3)
                      and beta(1) integrin expression in U87 cells after both
                      radiation types was observed. beta(1) integrin expression in
                      HCT116 cells was increased after X-rays but decreased after
                      heavy ion irradiation.Results suggest that irradiation of
                      tumor cells can modulate their migratory behavior. An
                      increased migration, as shown with U87, leaves a higher
                      probability of metastatic induction after irradiation of
                      solid tumors in vivo, whereas an invariably reduced tumor
                      cell migration, as shown after heavy ion treatment, could
                      diminish the hazard of radiation-induced metastasis. As
                      integrin expression and migration were only partially
                      correlated, other migration-related surface molecules may be
                      more relevant for radiation effects on tumor cell motility.},
      keywords     = {Antigens, CD29 (NLM Chemicals) / Integrin beta3 (NLM
                      Chemicals)},
      cin          = {BIO},
      ddc          = {570},
      cid          = {I:(DE-Ds200)BIO-20160831OR354},
      pnm          = {899 - ohne Topic (POF3-899) / 310 - Krebsforschung
                      (POF1-300)},
      pid          = {G:(DE-HGF)POF3-899 / G:(DE-HGF)POF1-310},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:18058372},
      UT           = {WOS:000251361000017},
      doi          = {10.1080/09553000701753826},
      url          = {https://repository.gsi.de/record/186297},
}