000187701 001__ 187701
000187701 005__ 20230208173523.0
000187701 0247_ $$2CORDIS$$aG:(EU-Grant)701986$$d701986
000187701 0247_ $$2CORDIS$$aG:(EU-Call)H2020-MSCA-IF-2015$$dH2020-MSCA-IF-2015
000187701 0247_ $$2originalID$$acorda__h2020::701986
000187701 035__ $$aG:(EU-Grant)701986
000187701 150__ $$aMulti-modal interrogation of instinctive behaviours and intrahypothalamic connectivity$$y2016-03-01 - 2018-02-28
000187701 371__ $$aKing's College London$$dUnited Kingdom$$ehttps://www.kcl.ac.uk/index.aspx$$vCORDIS
000187701 372__ $$aH2020-MSCA-IF-2015$$s2016-03-01$$t2018-02-28
000187701 450__ $$aDRIVOME$$wd$$y2016-03-01 - 2018-02-28
000187701 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000187701 680__ $$aMammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly.
Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.
000187701 909CO $$ooai:juser.fz-juelich.de:659804$$pauthority$$pauthority:GRANT
000187701 909CO $$ooai:juser.fz-juelich.de:659804
000187701 970__ $$aoai:dnet:corda__h2020::eee0320827e5be725c17957b4328ab1b
000187701 980__ $$aG
000187701 980__ $$aCORDIS
000187701 980__ $$aAUTHORITY