000196892 001__ 196892
000196892 005__ 20230827173147.0
000196892 0247_ $$2CORDIS$$aG:(EU-Grant)715662$$d715662
000196892 0247_ $$2CORDIS$$aG:(EU-Call)ERC-2016-STG$$dERC-2016-STG
000196892 0247_ $$2originalID$$acorda__h2020::715662
000196892 035__ $$aG:(EU-Grant)715662
000196892 150__ $$aInvestigating Host-Microbial Interactions after Bariatric Surgery$$y2017-08-01 - 2025-01-31
000196892 371__ $$aImperial College of Science Technology and Medicine$$bImperial$$dUnited Kingdom$$ehttp://www.imperial.ac.uk$$vCORDIS
000196892 372__ $$aERC-2016-STG$$s2017-08-01$$t2025-01-31
000196892 450__ $$aEnteroBariatric$$wd$$y2017-08-01 - 2025-01-31
000196892 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000196892 680__ $$aObesity and related co-morbidities give rise to severe health and socioeconomic problems. Surgical treatment for obesity (bariatric surgery) is remarkably effective in the control of morbid obesity and rapid resolution of Type 2 Diabetes, and the number of such procedures is increasing rapidly in many obesity-prevalent countries. We, and others, have demonstrated that surgical interventions such as Roux-en-Y Gastric Bypass (RYGB) modulates gut hormone levels, induces systemic metabolic changes and results in the shift of the microbiome from Firmicutes to the Proteobacteria phylum. Although the gut microbiota have been implicated in the reduction of adiposity post-surgery, the long-term effect of altered gut microbiota on patients who have undergone RYGB, remains to be studied. Our recent data suggested that microbial activities are highly associated with inflammation and cancer. My research programme aims to investigate the RYGB-specific gut microbiota impacts on host physiology and colon cancer risk. To achieve this goal, I will employ a multidisciplinary approach that combines systems biology techniques with a bottom-up approach. This work will deliver phenotypic and mechanistic characterisation of the interplay between the host and the gut microbiota. The research findings will significantly contribute towards the understanding of fundamental molecular and cellular processes that are key in host and gut microbiota interactions. This will provide knowledge-based evidence of the gut microbial impact on human physiology, and has the potential to unravel novel prevention targets and promote a more thorough healthcare strategy for bariatric patients.
000196892 909CO $$ooai:juser.fz-juelich.de:821539$$pauthority$$pauthority:GRANT
000196892 909CO $$ooai:juser.fz-juelich.de:821539
000196892 970__ $$aoai:dnet:corda__h2020::67ed19d3bd91c52cff4a6fd1c4367e2e
000196892 980__ $$aG
000196892 980__ $$aCORDIS
000196892 980__ $$aAUTHORITY