Record #197507 - GSI Repository

Train2Target

An integrated mulTidisciplinary appRoach towards a new generAtIon of aNtibiotics: Targeting function and cross-talk of bacterial Envelope proTein machineries

Coordinator	CNRS - Institut des Sciences Biologiques ; BIOVERSYS AG ; UNION THERAPEUTICS AS ; NAICONS SRL ; UNIVERSITY OF NEWCASTLE UPON TYNE ; AICURIS ANTI-INFECTIVE CURES GMBH ; University of Naples Federico II ; University of Milan ; Université Catholique de Louvain ; VU University Amsterdam ; University of Birmingham
Grant period	2017-01-01 - 2020-12-31
Funding body	European Union
Call number	H2020-MSCA-ITN-2016
Grant number	721484
Identifier	G:(EU-Grant)721484

Note: Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens. The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads. The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification. Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.

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Record created 2016-11-19, last modified 2023-02-12

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