Record #203480 - GSI Repository

VestibVis

Visual and vestibular processing in secondary visual cortex

Coordinator	The Francis Crick Institute
Grant period	2017-03-01 - 2019-02-28
Funding body	European Union
Call number	H2020-MSCA-IF-2016
Grant number	747902
Identifier	G:(EU-Grant)747902

Note: Spatial navigation requires the integration of visual and vestibular inputs to build a representation of space. Connectivity studies have shown that the secondary visual cortex (V2) of mice receives bottom-up inputs from primary visual cortex and anterior thalamus, conveying respectively visual and vestibular information, and feedback top-down inputs from the retrosplenial cortex. The aims of this project are to determine the visual and vestibular tuning of layer 5 pyramidal neurons in V2, how these inputs are recruited and interact when the mouse is engaged in a spatial navigation task, and how they are modulated by retrosplenial inputs. This will be accomplished using a combination of population calcium imaging or whole-cell patch-clamp recordings of layer 5 neurons, coupled with sensory stimulation and optogenetic activation or inhibition of sensory or top-down inputs and behavioural experiments.

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Record created 2017-06-14, last modified 2023-02-12

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