000205192 001__ 205192
000205192 005__ 20230212173738.0
000205192 0247_ $$2CORDIS$$aG:(EU-Grant)715732$$d715732
000205192 0247_ $$2CORDIS$$aG:(EU-Call)ERC-2016-STG$$dERC-2016-STG
000205192 0247_ $$2originalID$$acorda__h2020::715732
000205192 035__ $$aG:(EU-Grant)715732
000205192 150__ $$aSTEM CELL MODELS TO UNRAVEL THE SUSCEPTIBILITY AND RESILIENCE TO DEVELOP HEART FAILURE$$y2017-03-01 - 2022-02-28
000205192 371__ $$aACADEMISCH ZIEKENHUIS GRONINGEN$$bUNIVERSITAIR MEDISCH CENTRUM GRONINGEN$$dNetherlands$$ehttp://www.umcg.nl$$vCORDIS
000205192 372__ $$aERC-2016-STG$$s2017-03-01$$t2022-02-28
000205192 450__ $$aSTOP-HF$$wd$$y2017-03-01 - 2022-02-28
000205192 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000205192 680__ $$aThe overarching objective of STOP-HF is to generate human induced pluripotent stem cells (hiPSC) derived cardiomyocytes from two specific forms of heart failure (HF) with a clear trigger to unravel common pathophysiological mechanisms involved in the early development of HF. The project is focused on two specific forms of HF, both with a clear trigger: pregnancy and anthracyclines. 

Better understanding of early molecular pathways leading to HF and knowledge about inter-individual susceptibility is needed. 
For detection of early changes on a molecular level cardiac tissue is needed. 
Generation of patient specific cardiac cells from skin fibroblasts (hiPSC technology) is a novel and innovative approach.

SPECIFIC OBJECTIVES 
1. Fabrication and maturation of 3D cardiac tissue from hiPS derived cardiomyocytes.
2. Generate and characterize hiPS derived cardiomyocytes and endothelial cells from females with pregnancy induced HF and unravel differences on transcriptome level.
3. Generate and characterize hiPSC derived cardiomyocytes from patients with high susceptibility and resilience to develop anthracycline-induced HF and compare them on transcriptome level. 
4. Integrate the results for coding and non-coding RNAs from objective 1+2 and identify overlapping pathways. 
5. Validate discoveries on transcriptome level in vitro, in vivo and apply for the development of HF in the general population.

WORKPACKAGES
WP1: Optimize fabrication and maturation of 3D cardiac tissue from hiPS derived cardiomyocytes
WP 2A:Validate the model and compare hiPS derived cardiomyocytes and endothelial cells from PPCM and healthy sisters on transcriptome level;
WP 2B:Validate the model and compare hiPS derived cardiomyocytes from both patients with high susceptibility and resilience to develop HF after anthracyclins on transcriptome level;
WP 3:Integration of transcriptome data from WP 2A+2B;
WP 4:Validation of novel pathways in vitro, in vivo and new onset HF in the general population.
000205192 909CO $$ooai:juser.fz-juelich.de:833969$$pauthority$$pauthority:GRANT
000205192 909CO $$ooai:juser.fz-juelich.de:833969
000205192 970__ $$aoai:dnet:corda__h2020::1a5ea24ccddb2617f86eda0358efdfba
000205192 980__ $$aG
000205192 980__ $$aCORDIS
000205192 980__ $$aAUTHORITY