Record #232933 - GSI Repository

QTB4AMR

Utilizing an innovative chemical platform to defeat antimicrobial resistance

Coordinator	QURETECH BIO AB
Grant period	2019-08-01 - 2020-01-31
Funding body	European Union
Call number	H2020-SMEInst-2018-2020-1
Grant number	877114
Identifier	G:(EU-Grant)877114

Note: We tackle the challenges posed by the emergence of antimicrobial resistance (AMR) with a conceptually new approach. We have established a scalable chemical platform for the development of novel antibiotic resistance breakers (ARBs). Our compounds sensitize the pathogen and restore the effectiveness of standard-of-care antibiotics. By circumventing the painstaking process of discovering and developing new antibiotics, we bring forth a more cost-effective approach to confront the emergence of AMR. Allowing pharmaceutical companies to protect decades worth of R&D efforts and billions of euros in development costs, we present them with an attractive value proposition. Our platform enables the fast, high-yield production of ARBs against gram-positive bacteria (GmPcides). Our compounds have displayed effectiveness against two of the most threatening drug-resistant pathogens MRSA and VRE. Moreover, the compounds exhibit a strong in vivo synergy with two of the world’s most essential antibiotics Gentamicin and Vancomycin.

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Record created 2020-09-04, last modified 2023-02-12

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