000238616 001__ 238616
000238616 005__ 20210924173038.0
000238616 0247_ $$2Medical Research Council$$aG:(GEPRIS)12469998$$d12469998
000238616 0247_ $$2I:(DE-588)1065079516$$aG:(Dimensions)grant.4790258$$dgrant.4790258
000238616 035__ $$aG:(GEPRIS)12469998
000238616 150__ $$aDie Rolle von RIM 1 alpha und seinen Isoformen bei der Ausbildung und Funktion der präsynaptischen aktiven Zone$$y2005-01-01 - 2006-12-31
000238616 5101_ $$0I:(DE-588b)2007744-0$$aGerman Research Foundation
000238616 680__ $$aThe so-called long-term potentiation (long term potentiation, LTP) in the brain is attributed a role in learning and memory formation. The proposed research project is to test the hypothesis whether the presynaptic protein RIM (Rab3-interactive molecule) a key role takes in a cascade of events that lead to a presynaptic form of long-term potentiation in the hippocampus and cerebellum. The work is divided into three parts: 1. Investigation of the cellular mechanisms; by RIM1¿ (a RIM isoform) is brought to emerging and mature synapses. 2. It should be investigated whether RIM1¿ is dynamically associated with the places where neurotransmitters are released into the synapse (active zone) or whether RIM fulfills its function as an integral structural protein of the cytoskeleton of the active zone. 3. Investigation; whether RIM1¿ dynamic association important presynaptic proteins (such as Munc13, Bassoon) regulated with the active zone.
000238616 909CO $$ooai:juser.fz-juelich.de:893639$$pauthority$$pauthority:GRANT
000238616 909CO $$ooai:juser.fz-juelich.de:893639
000238616 980__ $$aG
000238616 980__ $$aAUTHORITY