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Rolle des Neurofibromin bei hippokampaler Funktion und Plastizität
Note: I neurofibromatosis (NF1) is a common hereditary disease which is associated with learning and memory disorders. Decisive insights into the relationships of the NF1-associated learning and memory impairments underlying molecular and cellular mechanisms have been developed in mouse models of the disease. Remains unclear which central nervous system cell types are responsible for the formation of NF1-associated learning deficits. In the project proposed here transgenic mice with a cell-type specific deletion of the NF1 gene is to be determined (in inhibitory neurons, excitatory neurons or astrocytes) by investigating what is the critical cellular localization of the genetic lesion for training NF1-associated learning deficits. By studying potential structural correlates of learning and memory in the hippocampus (synaptic plasticity, hippocampal neurogenesis) in these transgenic mice are insights are obtained, how changes at the molecular level lead to disturbances of cellular functions, resulting in impairment of cognitive functions. Ultimately, should a based on these findings, pharmacological treatment of NF1-associated learning deficits are being tested in an animal model. About the Insights into the Pathogenesis of NF1-associated learning deficits, this project could provide valuable insights into normal learning and memory functions underlying biological mechanisms.
| Grant period | 2004-01-01 - 2008-12-31 |
| Funding body | German Research Foundation |
| DFG | |
| Grant number | grant.4787308 |
| Identifier | G:(GEPRIS)5433545 |
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Record created 2021-07-01, last modified 2021-09-24