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BARB

Biomedical Applications of Radioactive ion Beams

Grant period2020-10-01 - 2025-09-30
Funding bodyEuropean Union
Call numberERC-2019-ADG
Grant number883425
IdentifierG:(EU-Grant)883425

Note: Cancer remains one of the main causes of death worldwide. In 2018, >50% cancer patients in Europe underwent radiotherapy. While over 80% were treated using high-energy X-rays, the number of patients receiving accelerated protons or heavy ions (charged particle therapy: CPT) is rapidly growing, with nearly 200,000 patients treated up till now. Although CPT offers a better depth-dose distribution compared to common X-ray based techniques, range uncertainty and poor image guidance still limit its application. Improving accuracy is key to broadening the applicability of CPT. In BARB, we will open a new paradigm in the clinical use of CPT by using high-intensity radioactive ion beams (RIB), produced at GSI/FAIR-phase-0 in Darmstadt, for simultaneous treatment and visualization. This will reduce range uncertainty and extend the applicability of CPT to treatment of small lesions (e.g. metastasis and heart ventricles) with unprecedented precision. The Facility for Antiprotons and Ion Research (FAIR) is currently under construction at GSI. RIB are one of the main tools for basic nuclear physics studies in the new facility. As part of the ongoing FAIR-phase-0, an intensity upgrade will increase the light ion currents in the existing SIS18 synchrotron. Within this project BARB, we will study four b+ emitters (10,11C, and 14,15O) and build an innovative hybrid detector for online positron emission tomography (PET) and g-ray imaging. This novel detector will acquire both prompt g-rays during the beam-on phase of the pulsed synchrotron beam delivery, and the delayed emission from b+ annihilation during the pulse intervals. The technique will be further validated in vivo by applying it to treatment of small tumors in a mouse model. BARB will exploit the potential of the Bragg peak in medicine. The project will tweak RIB production in nuclear physics and validate the therapeutic potential of RIB therapy in vivo by empowering simultaneous treatment and visualization.
   

Recent Publications

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Experimental assessment of novel PET detector components for online imaging of radioactive ion beams
Physics in medicine and biology 70(19), 195008 () [10.1088/1361-6560/ae0674] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Accelerator technologies for proton and ion beam therapy
Nature physics 21(9), 1363 - 1373 () [10.1038/s41567-025-02994-7] BibTeX | EndNote: XML, Text | RIS

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Image-guided treatment of mouse tumours with radioactive ion beams
Nature physics 21(10), 1648 - 1656 () [10.1038/s41567-025-02993-8] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Precision of the PET activity range during irradiation with $^{10}C$, $^{11}C$, and $^{12}C$ beams
Physics in medicine and biology 68(1), 015003 () [10.1088/1361-6560/aca5e8] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Quasi-real-time range monitoring by in-beam PET: a case for $^{15}O$
Scientific reports 13(1), 18788 () [10.1038/s41598-023-45122-2] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?
Cancers 15(18), 4494 () [10.3390/cancers15184494] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Emerging technologies for cancer therapy using accelerated particles
Progress in particle and nuclear physics 131, 104046 () [10.1016/j.ppnp.2023.104046] BibTeX | EndNote: XML, Text | RIS

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Production and separation of positron emitters for hadron therapy at FRS-Cave M
Nuclear instruments & methods in physics research / B 541, 114 - 116 () [10.1016/j.nimb.2023.04.026] BibTeX | EndNote: XML, Text | RIS

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Potential benefits of using radioactive ion beams for range margin reduction in carbon ion therapy
Scientific reports 12(1), 21792 () [10.1038/s41598-022-26290-z] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Depth dose measurements in water for $^{11}C$ and $^{10}C$ beams with therapy relevant energies
Nuclear instruments & methods in physics research / A 1043, 167464 () [10.1016/j.nima.2022.167464] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

All known publications ...
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 Record created 2021-10-10, last modified 2023-02-12
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