000243144 001__ 243144
000243144 005__ 20230214173930.0
000243144 0247_ $$2CORDIS$$aG:(EU-Grant)101023270$$d101023270
000243144 0247_ $$2CORDIS$$aG:(EU-Call)H2020-MSCA-IF-2020$$dH2020-MSCA-IF-2020
000243144 0247_ $$2originalID$$acorda__h2020::101023270
000243144 035__ $$aG:(EU-Grant)101023270
000243144 150__ $$aDesign and construction of programmed protocells for intercellular networks and biomimetic communications$$y2021-08-01 - 2023-07-31
000243144 372__ $$aH2020-MSCA-IF-2020$$s2021-08-01$$t2023-07-31
000243144 450__ $$aPROGRAMED PROTOCELLS$$wd$$y2021-08-01 - 2023-07-31
000243144 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000243144 680__ $$aArtificial cellular counterparts (protocells) can be fabricated to produce explicit biomimetic outcomes such as RNA-mediated replication, gene expression, metabolism, etc. These synthetic mimics with cell-like traits, aim to answer fundamental questions regarding origin of cellularity from non-living components. However, minimal levels of structural/organisational complexity exhibited in current protocell designs, limits their application potential. The aim of this proposal is to use bottom-up approaches to precisely design and construct complex protocells through membrane coupled appendages and produce interactive protocellular communities which will recognize, sort and processes chemical signals through collective behaviour.  The self-assembled protocellular colonies will be sequestered with complex enzymatic reaction networks which operate spontaneously and synergistically reminiscent to living cells. Several important functions such as selective formation of protocellular consortia, mimicking important biological functions such as IDH-kinase/phosphatase (AceK) circuitry from the Krebs cycle, redox-homeostasis, self-protection from chemical degradation will increase the complexity of the protocellular constructs producing the first example of functional proto-colonies. The expertise of the applicant in the field of organic synthesis, supramolecular chemistry and out-of-equilibrium self-assembly will be employed by the multidisciplinary and evolving field of protocells pioneered by the hosting group of Professor Stephen Mann FRS at the University of Bristol. The combined research efforts of the applicant and the Mann group will result in the successful realization of programmable protocells resulting in active self-assembling protocellular constructs and build their advanced forms capable of spatio-temporal self-sorting, self-regulation and higher-order organization and function.
000243144 909CO $$ooai:juser.fz-juelich.de:899584$$pauthority$$pauthority:GRANT
000243144 909CO $$ooai:juser.fz-juelich.de:899584
000243144 980__ $$aG
000243144 980__ $$aCORDIS
000243144 980__ $$aAUTHORITY