Record #243326 - GSI Repository

BENOVELTY

Saturated bioisosteres of benzene and their application in drug design

Grant period	2021-04-01 - 2026-03-31
Funding body	European Union
Call number	ERC-2020-COG
Grant number	101000893
Identifier	G:(EU-Grant)101000893

Note: More than 500 of all existing drugs are phenyl-containing organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical approaches towards novel drug-like “chemical space.” In this project, we will address this issue by developing novel saturated bioisosteres for ortho- and meta-substituted benzenes, and incorporate them into several known drugs (intiinflamatory Aceclofenac, antiviral Tipranavir, antihypertensive Oxprenolol, etc) to provide novel patent-free analogues with improved physico-chemical and biological properties.

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Record created 2021-10-10, last modified 2023-02-08

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