000243693 001__ 243693
000243693 005__ 20230214173936.0
000243693 0247_ $$2CORDIS$$aG:(EU-Grant)101016964$$d101016964
000243693 0247_ $$2CORDIS$$aG:(EU-Call)H2020-ICT-2020-2$$dH2020-ICT-2020-2
000243693 0247_ $$2originalID$$acorda__h2020::101016964
000243693 035__ $$aG:(EU-Grant)101016964
000243693 150__ $$aRevealing drug tolerant persister cells in cancer using contrast enhanced optical coherence and photoacoustic tomography$$y2021-01-01 - 2024-12-31
000243693 372__ $$aH2020-ICT-2020-2$$s2021-01-01$$t2024-12-31
000243693 450__ $$aREAP$$wd$$y2021-01-01 - 2024-12-31
000243693 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000243693 680__ $$aCancer treatment faces a major problem: it ultimately stops working for many patients because the tumor becomes resistant. The cellular origin of relapse is often linked to drug tolerant persister (DTP) cells, which survive treatment and can remain for years. Because of their scarcity and heterogeneity, the detection of DTP cells remains a technological challenge of enormous clinical importance. The objective of REAP is to develop two next generation multimodal imaging systems to reveal DTPs. A triple modal two-photon laser scanning optical coherence photoacoustic microscopy system will be built for the in vitro characterization of cancer organoids. Additionally, a dual-modality optical coherence photoacoustic tomography system will be implemented to visualize tumors in vivo in a mouse model. To enable greatly increased sensitivity and specificity, a new type of contrast agent based on biofunctionalized nanoparticles with tailor-made optical properties will be fabricated to specifically label DTPs. For improved imaging performance, several further technological advancements are targeted. Photoacoustic excitation will be realized using innovative microchip lasers addressing the needs for high-energy pulses, high-repetition rate, and multi-wavelength emission. To achieve the required resolution, novel photoacoustic detectors based on integrated optical micro-ring resonator technology will be developed with the potential to completely replace conventional piezoelectric ultrasound transducers. Furthermore, image acquisition speed will be increased by an order of magnitude with the help of an innovative laser source based on photonic integrated circuits at 780 nm. Finally, real-time data handling will be explored along with deep learning-based automatic analysis algorithms. The combined innovation in laser sources, detector technology, nanoparticles, and deep learning-based algorithms will create radically new imaging solutions reaching numerous applications.
000243693 909CO $$ooai:juser.fz-juelich.de:900133$$pauthority$$pauthority:GRANT
000243693 909CO $$ooai:juser.fz-juelich.de:900133
000243693 980__ $$aG
000243693 980__ $$aCORDIS
000243693 980__ $$aAUTHORITY