Record #243790 - GSI Repository

OCHRE

Oat CHRomosome Evolution and drivers enabling widespread terminal intergenomic translocations in polyploid species

Grant period	2020-10-29 - 2021-10-28
Funding body	European Union
Call number	H2020-IBA-MSCA-SNLS-2020
Grant number	101006417
Identifier	G:(EU-Grant)101006417

Note: Comparative genetic analysis of grasses, one of the most widely distributed plant families and including the three most important human foods, has demonstrated that different groups differ in the evolutionary presence of intergenomic chromosome translocations in polyploid species, including the important crops. The overall goal of our research group is to define the nature and mechanism of terminal intergenomic translocations in oats (Avena) where these are frequent, allowing us to model their contribution to cereal genome evolution. We hypothesize that terminal translocations between oat genomes are related to transposable element activity, a decrease in DNA methylation, and histone modifications that are differential between the genomes. In our main project we proposed a focused series of complementary molecular cytogenetic, bioinformatic, and epigenetic studies on oat and wheat genomes to characterize this physical genome rearrangement process. We will develop translocation-specific probes and find breakpoints using advanced bioinformatic tools. A comprehensive model illustrating the potential mechanisms involved in terminal intergenomic translocations will be elucidated by the simultaneous hybridization with the use of genome- and translocation-specific probes, retrotransposon sequences, and immunostaining. The research will reveal why genomes of oats show frequent intergenomic translocations, playing a significant role in their evolution, in contrast to wheats where the translocations are rare. Bioinformatic analyses for high throughput sequencing data are a huge part of our project. As a disabled person, I need additional support for the purchase of a computer and laptop to perform advanced bioinformatic analyses in the shortest possible time, and thus reduce negative effects of computers on my health. I also apply for monitors with eye care technology, and desk and contour chair adapted to the need of disabled person.

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Record created 2021-10-10, last modified 2023-02-19

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