000244092 001__ 244092
000244092 005__ 20230214173940.0
000244092 0247_ $$2CORDIS$$aG:(EU-Grant)101024970$$d101024970
000244092 0247_ $$2CORDIS$$aG:(EU-Call)H2020-MSCA-IF-2020$$dH2020-MSCA-IF-2020
000244092 0247_ $$2originalID$$acorda__h2020::101024970
000244092 035__ $$aG:(EU-Grant)101024970
000244092 150__ $$aThe molecular basis of ineffective erythropoiesis in Sickle Cell Disease$$y2022-02-01 - 2024-01-31
000244092 372__ $$aH2020-MSCA-IF-2020$$s2022-02-01$$t2024-01-31
000244092 450__ $$aInEr-SICKLE$$wd$$y2022-02-01 - 2024-01-31
000244092 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000244092 680__ $$aIn this project, I will investigate ineffective erythropoiesis as a contributing factor and potential therapeutic target in the pathogenesis of sickle cell disease (SCD), one of the most prevalent genetic disorders in man and a global health problem. I will employ cutting-edge proteomic and genomic approaches to investigate in detail deregulation of the master erythroid transcription factor GATA1 as a result of oxidative stress in sickle red blood cells, as the basis for ineffective erythropoiesis in SCD. I will also investigate whether restoring GATA1 functions can alleviate ineffective erythropoiesis, thus providing alternative therapeutic opportunities in treating SCD. Lastly, I will generate novel cellular models for SCD from patients that can be used in dissecting the pathophysiology of SCD and in screening for agents that can alleviate IE and sickling. My project will generate novel insight into SCD pathogenesis and tools that can lead to the development of novel therapeutic approaches. My background in SCD cellular pathophysiology is highly complementary to those of my supervisors, Prof. John Strouboulis who is an expert in GATA1 functions in molecular erythropoiesis and Prof. David Rees, who is a world leading clinician in pediatric sickle cell disease. I stand to benefit greatly by receiving excellent training in -omics, functional assays in molecular erythropoiesis and in clinical aspects of SCD, that will enable me to progress into a career as an independent investigator.
000244092 909CO $$ooai:juser.fz-juelich.de:900532$$pauthority$$pauthority:GRANT
000244092 909CO $$ooai:juser.fz-juelich.de:900532
000244092 980__ $$aG
000244092 980__ $$aCORDIS
000244092 980__ $$aAUTHORITY