000244243 001__ 244243
000244243 005__ 20230212174156.0
000244243 0247_ $$2CORDIS$$aG:(EU-Grant)884235$$d884235
000244243 0247_ $$2CORDIS$$aG:(EU-Call)ERC-2019-ADG$$dERC-2019-ADG
000244243 0247_ $$2originalID$$acorda__h2020::884235
000244243 035__ $$aG:(EU-Grant)884235
000244243 150__ $$aTackling Multi-Host Pathogenicity of Xylella by Assisted Immunity$$y2021-01-01 - 2025-12-31
000244243 372__ $$aERC-2019-ADG$$s2021-01-01$$t2025-12-31
000244243 450__ $$aMultiX$$wd$$y2021-01-01 - 2025-12-31
000244243 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000244243 680__ $$aThis project addresses a complex problem in agriculture and will identify the process of multi-host pathogenicity.

Emerging and re-emerging disease epidemics represent ongoing challenges to cultivation of crop plants, a global threat to food security and social stability. One of the recent disease epidemics is caused by Xylella fastidiosa, a generalist bacterium that infects a broad range of hosts, now spreading in Europe and threatening olive production. How pathogens colonize in multiple, genetically diverse species across families is poorly understood.

X. fastidiosa colonizes xylem vessels, dead cells of the vasculature. I hypothesize that the more complex nature of multi-host pathogen interactions could be explained by a common virulence strategy that depends on environmental circumstances, in terms of resources and immune defences to be overcome. We will use a multi-host approach combined with dual transcriptomics for the systematic analysis of bacterial and plant signatures associated with disease caused by X. fastidiosa. Identifying virulence factors and plant immunity determinants will drive our understanding of host susceptibility.

Of translational scientific interest, we will reveal immune receptors that control X. fastidiosa infection. Using this knowledge, we will assist the immune system at different levels of organization of plant tissues by targeted expression of immune receptors. This is high risk/high gain but of strategic relevance for my long-term goal to reduce disease in crops without yield penalties.

At its completion, this project will deliver molecular determinants to disease control and an approach to assist immunity in the vasculature, and thus will pave the way for applying similar strategies to other important vascular pathogens. It will also advance our understanding of the more complex nature of multi-host pathogen interactions and our conceptual views of host range determinants.
000244243 909CO $$ooai:juser.fz-juelich.de:900683$$pauthority$$pauthority:GRANT
000244243 909CO $$ooai:juser.fz-juelich.de:900683
000244243 980__ $$aG
000244243 980__ $$aCORDIS
000244243 980__ $$aAUTHORITY