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001     244668
005     20230214173945.0
024 7 _ |a G:(EU-Grant)101023536
|d 101023536
|2 CORDIS
024 7 _ |a G:(EU-Call)H2020-MSCA-IF-2020
|d H2020-MSCA-IF-2020
|2 CORDIS
024 7 _ |a corda__h2020::101023536
|2 originalID
035 _ _ |a G:(EU-Grant)101023536
150 _ _ |a Neural Mechanisms of Action-Selection During Sensory Conflict
|y 2022-09-01 - 2024-08-31
372 _ _ |a H2020-MSCA-IF-2020
|s 2022-09-01
|t 2024-08-31
450 _ _ |a CourtEscape
|w d
|y 2022-09-01 - 2024-08-31
510 1 _ |0 I:(DE-588b)5098525-5
|a European Union
|2 CORDIS
680 _ _ |a Prioritising the most urgent goal according to the context and physiological needs is crucial for the success of any organism. Action-selection processes are often disrupted in neuropathologies, such as Parkinson's disease, Alzheimer's disease and addiction; however, the underlying neuronal mechanisms are not well understood. Crucially, how the brain evaluates sensory conflicting options and selects an appropriate action remains unknown. I will tackle this question using a novel assay in which Drosophila fruit fly males are confronted with visual threats during courtship, which creates a conflict between survival and reproduction. Capitalising on refined genetic tools, I aim to unravel neural mechanisms that govern the selection between competing options. I will carry out a behavioural screen to identify neurons that allow the fly to choose between courting a mate and escaping a threat. From an in silico screen of Gal4 fly lines targeting defined cells, I will select lines based on their potential connectivity with courtship-command neurons. Using optogenetic tools, I will identify neurons that, when activated or inhibited, prevent males from blocking courtship in response to the threat. Next, I will ask if these cells respond to the threat in live Ca2+ imaging studies, and test if they are linked with the courtship circuitry using pre and post-synaptic markers and GRASP (to test potential synaptic connections). To probe if candidate neurons are functionally linked, I will manipulate the activity of upstream cells, and test the responses in downstream cells with Ca2+ imaging. This will allow me to build a map of the neural network of action-selection. Finally, I will test how external and internal state variables modulate action-selection. This study will provide insights into fundamental brain processes that may work in other animals, including humans.
909 C O |o oai:juser.fz-juelich.de:901108
|p authority:GRANT
|p authority
909 C O |o oai:juser.fz-juelich.de:901108
980 _ _ |a G
980 _ _ |a CORDIS
980 _ _ |a AUTHORITY

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