Record #254381 - GSI Repository

DFG project G:(GEPRIS)316656770

Paraplegie Prävention bei der Therapie Thorakoabdominaler Aorten-Aneurysmen durch gestufte 'Minimal-invasive Segmentarterien Coil-Embolisation' (MISACE): eine randomisiert-kontrollierte multizentrische Studie (PAPA_ARTiS)

Coordinator	Professor Dr. Christian Etz
Grant period	2017 - 2025
Funding body	Deutsche Forschungsgemeinschaft
	DFG
Identifier	G:(GEPRIS)316656770

Note: Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time, but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures compromise spinal cord blood supply acutely and permanently, frequently leading to paraplegia, particularly for aneurysms involving crucial segmental arteries, i.e. thoracoabdominal aortic aneurysms of Crawford type II & III. Although various strategies have achieved a remarkable decrease in the incidence of paraplegia, it is still no less than 10-20%. However, the principal investigator’s team has recently found that the deliberate staged occlusion of the segmental arteries to the paraspinous collateral network finally supplying the spinal cord can trigger arterial collateralization, thus stabilizing blood supply from alternate inflow sources and preventing ischaemia. This translated to a clinically available therapeutic option, ‘minimally invasive segmental artery coil embolization’ (MISACE), which proceeds in a ‘staged’ manner to occlude groups of arteries under highly controlled conditions, after which, time must be allowed for arteriogenesis to build a robust collateral blood supply. PAPA-ARTiS is a trial to demonstrate that a staged treatment approach, selectively occluding segmental arteries prior to curative aneurysm treatment, can reduce paraplegia and mortality dramatically.

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Record created 2023-01-19, last modified 2025-01-10

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