DFG project G:(GEPRIS)251818836
Hepatitis C virus-induced proinflammatory network and host antiviral innate immune response (A08)
| Coordinator | Professor Dr. Ying Zhu, Ph.D. |
| Grant period | - 2017 |
| Funding body | Deutsche Forschungsgemeinschaft |
| | DFG |
| Identifier | G:(GEPRIS)251818836 |
⇧ TRR 60: Interaktion von Viren mit Zellen des Immunsystems bei persistierenden Virusinfektionen: Grundlagen für Immuntherapie und Impfungen ⇧
Note: Our previous study demonstrates that human peripheral blood mononuclear cells (PBMCs) are a good model to investigate inflammation and host immune responses. Most viruses trigger robust cytokines expression in PBMCs although viral infection is not productive. Using a combination of cell cultures, PBMCs models and clinical biopsy samples analyses, we are trying to answer fundamental questions in the virally induced proinflammatory network and the host antiviral innate immune response. In the present project, we expect to answer the following questions:1. What is the exact role of host MVP in IFN signaling pathways and the proteins interacting with MVP in the process of hepatitis viral infection?2. How do aberrant epigenetic modifications regulate inflammatory cytokine expression and host antiviral innate immune responses?
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