000286748 001__ 286748
000286748 005__ 20240928180449.0
000286748 0247_ $$aG:(GEPRIS)251818836$$d251818836
000286748 035__ $$aG:(GEPRIS)251818836
000286748 040__ $$aGEPRIS$$chttp://gepris.its.kfa-juelich.de
000286748 150__ $$aHepatitis C virus-induced proinflammatory network and host antiviral innate immune response (A08)$$y- 2017
000286748 371__ $$aProfessor Dr. Ying Zhu, Ph.D.
000286748 450__ $$aDFG project G:(GEPRIS)251818836$$wd$$y- 2017
000286748 5101_ $$0I:(DE-588b)2007744-0$$aDeutsche Forschungsgemeinschaft$$bDFG
000286748 550__ $$0G:(GEPRIS)47100475$$aTRR 60: Interaktion von Viren mit Zellen des Immunsystems bei persistierenden Virusinfektionen: Grundlagen für Immuntherapie und Impfungen$$wt
000286748 680__ $$aOur previous study demonstrates that human peripheral blood mononuclear cells (PBMCs) are a good model to investigate inflammation and host immune responses. Most viruses trigger robust cytokines expression in PBMCs although viral infection is not productive. Using a combination of cell cultures, PBMCs models and clinical biopsy samples analyses, we are trying to answer fundamental questions in the virally induced proinflammatory network and the host antiviral innate immune response. In the present project, we expect to answer the following questions:1. What is the exact role of host MVP in IFN signaling pathways and the proteins interacting with MVP in the process of hepatitis viral infection?2. How do aberrant epigenetic modifications regulate inflammatory cytokine expression and host antiviral innate immune responses?
000286748 909CO $$ooai:juser.fz-juelich.de:953491$$pauthority$$pauthority:GRANT
000286748 909CO $$ooai:juser.fz-juelich.de:953491
000286748 980__ $$aG
000286748 980__ $$aAUTHORITY