286748 20240928180449.0 G:(GEPRIS)251818836 G:(GEPRIS)251818836 251818836 GEPRIS http://gepris.its.kfa-juelich.de Hepatitis C virus-induced proinflammatory network and host antiviral innate immune response (A08) - 2017 Professor Dr. Ying Zhu, Ph.D. DFG project G:(GEPRIS)251818836 d - 2017 Deutsche Forschungsgemeinschaft I:(DE-588b)2007744-0 DFG G:(GEPRIS)47100475 TRR 60: Interaktion von Viren mit Zellen des Immunsystems bei persistierenden Virusinfektionen: Grundlagen für Immuntherapie und Impfungen t Our previous study demonstrates that human peripheral blood mononuclear cells (PBMCs) are a good model to investigate inflammation and host immune responses. Most viruses trigger robust cytokines expression in PBMCs although viral infection is not productive. Using a combination of cell cultures, PBMCs models and clinical biopsy samples analyses, we are trying to answer fundamental questions in the virally induced proinflammatory network and the host antiviral innate immune response. In the present project, we expect to answer the following questions:1. What is the exact role of host MVP in IFN signaling pathways and the proteins interacting with MVP in the process of hepatitis viral infection?2. How do aberrant epigenetic modifications regulate inflammatory cytokine expression and host antiviral innate immune responses? oai:juser.fz-juelich.de:953491 authority:GRANT authority G AUTHORITY oai:juser.fz-juelich.de:953491