000307152 001__ 307152
000307152 005__ 20240928181412.0
000307152 0247_ $$aG:(GEPRIS)5455940$$d5455940
000307152 035__ $$aG:(GEPRIS)5455940
000307152 040__ $$aGEPRIS$$chttp://gepris.its.kfa-juelich.de
000307152 150__ $$aAllorecognition in Ciona intestinalis: molecular basis for self-sterility in a hermaphroditic urochordate$$y2005 - 2012
000307152 371__ $$aDr. Konstantin Khalturin
000307152 450__ $$aDFG project G:(GEPRIS)5455940$$wd$$y2005 - 2012
000307152 5101_ $$0I:(DE-588b)2007744-0$$aDeutsche Forschungsgemeinschaft$$bDFG
000307152 680__ $$aHow ancestral chordates discriminate between self and nonself is not known. In an unbiased screening approach to identify Botryllus genes whose expression is altered in response to allogeneic contacts we recently identified a homolog of the CD94 / NKR-P1 receptor in Botryllus (Khalturin et al, 2003) as well as in the solitary tunicates Ciona intestinalis and C. savignyii (Khalturin et al., 2004a). In vertebrates, ligands to CD94 belong to the HLA-E group of nonclassical MHC I. Since the genomes of urochorda tes do not contain any MHC-like genes, the nature of the ligand of the CD94-like receptor protein in urochordates remains enigmatic. Here we propose to further analyse the mechanisms of allorecognition in ancestral chordates. Specifically, we suggest to (i) identify the ligand for CD94-like proteins in Botryllus and Ciona; (ii) analyse the putative NK locus in Ciona and Botryllus; and (iii) screen for proteins with high degree of interindividual variability in Ciona. The results will shed light on the evol ution of the innate immune system in deuterostomes as well as on the emergence of adaptive immunity.
000307152 909CO $$ooai:juser.fz-juelich.de:974027$$pauthority$$pauthority:GRANT
000307152 909CO $$ooai:juser.fz-juelich.de:974027
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000307152 980__ $$aAUTHORITY