Record #310482 - GSI Repository

DFG project G:(GEPRIS)52261075

Identifizierung der Rezeptorinteraktion von RF-amid-Peptiden auf molekularer Ebene

Coordinator	Professorin Dr. Annette G. Beck-Sickinger
Grant period	2007 - 2016
Funding body	Deutsche Forschungsgemeinschaft
	DFG
Identifier	G:(GEPRIS)52261075

Note: RF-amide-peptides consist of 8-26 amino acids in human and contain C-terminally a characteristic Arg-Phe-amide-dipeptide motif. Six RF-amide-peptides have been described in human. For the last two years this peptide family has gained significant interest mainly because of its pharmacologically important activities like modulation of pain, stress control, regulation of day/night rhythm and food intake. The peptides bind to 4 receptors in human that all belong to the family of G-protein coupled receptors. We recently could identify the ligand binding site of neuropeptide Y and based on these data we hypothesize a strong ionic and important interaction of the conserved Arg residue of the RF-amide peptides with residue Asp6.59 of the correspondent receptor. We plan to use synthetic peptide analogues, receptor mutagenesis and complementary interaction studies to identify the ligand binding pocket on a molecular level. This might contribute significantly to the overall understanding of binding and signal transduction of peptides that interact with GPCRs. Furthermore, our data could support drug development in these systems and clarify the important problem of ligand selectivity of RF-amide peptides. Owing to the evolutionary old family of RF-amide peptides we might contribute to a better understanding of the coevolution of ligands and receptors.

Recent Publications

There are no publications

Record created 2023-02-04, last modified 2024-09-28

Similar records

Add to personal basket
Export as Author List with IDs BibTeX (UTF-8), EndNote XML, EndNote Text, RIS, MARC, Print MARC, MARCXML, DC,
Request correction
Submit fulltext

GSI Homepage \| GSI Library \| English Deutsch \| guest :: login GSI Repository
Search	Submit	Personalize Your alerts Your baskets Your searches	Help