000332812 001__ 332812
000332812 005__ 20230219174910.0
000332812 0247_ $$2CORDIS$$aG:(EU-Grant)101047223$$d101047223
000332812 0247_ $$2CORDIS$$aG:(EU-Call)HORIZON-EIC-2021-PATHFINDEROPEN-01$$dHORIZON-EIC-2021-PATHFINDEROPEN-01
000332812 0247_ $$2originalID$$acorda_____he::101047223
000332812 035__ $$aG:(EU-Grant)101047223
000332812 150__ $$aNanoscale virus imaging X-ray microscope based on incoherent diffraction$$y2022-05-01 - 2026-04-30
000332812 372__ $$aHORIZON-EIC-2021-PATHFINDEROPEN-01$$s2022-05-01$$t2026-04-30
000332812 450__ $$aNanoXCAN$$wd$$y2022-05-01 - 2026-04-30
000332812 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000332812 680__ $$aCoronavirus disease (COVID-19) is an infectious disease that emerged in late 2019. By March 2020, the outbreak was declared a devastating pandemic and clearly illustrated the threat that viruses pose to our society. The characterization of viral structures and the identification of key proteins involved in each step of the cycle of infection are crucial to developing treatments. Yet imaging single viruses can only be performed in a few specialized centers in Europe, while every hospital could benefit from it.  NanoXCAN proposes to develop a tabletop virus imaging X-ray microscope, with foreseeable impact as revolutionary as the invention of super-resolved fluorescence microscopy, paving the way towards determination of structure and dynamics of matter to a large community. For this purpose, we will develop an original digital laser that delivers, on a daily operation, subwavelength focusing, reaching relativistic intensities at MHz repetition rates. This will be used to create a nano-source of hard X-rays from the Kalpha plasma emission of metallic nano-targets at an average power comparable to that of a synchrotron beamline.  We will capitalize on this high brilliance, high average power hard X-ray source to perform lensless nanoscale biomedical imaging based on recent findings in incoherent imaging and machine learning. All these ingredients will create a unique nanoscopy platform that our consortium will illustrate by imaging a single virus. In the future, our X-ray IDI microscope could help to study mechanisms involved in viral infection and antiviral design. X-rays have the advantage of performing in-situ non-destructive and non-invasive imaging over competing techniques. NanoXCAN will create a transformative positive effect on our economy and society by proposing this new technology for single virus imaging.
000332812 909CO $$ooai:juser.fz-juelich.de:999806$$pauthority:GRANT$$pauthority
000332812 909CO $$ooai:juser.fz-juelich.de:999806
000332812 980__ $$aG
000332812 980__ $$aCORDIS
000332812 980__ $$aAUTHORITY