000341728 001__ 341728
000341728 005__ 20230827173324.0
000341728 0247_ $$2CORDIS$$aG:(EU-Grant)190186802$$d190186802
000341728 0247_ $$2CORDIS$$aG:(EU-Call)HORIZON-EIC-2022-ACCELERATOR-01$$dHORIZON-EIC-2022-ACCELERATOR-01
000341728 0247_ $$2originalID$$acorda_____he::190186802
000341728 035__ $$aG:(EU-Grant)190186802
000341728 150__ $$aAdpative DBS$$y2023-03-01 - 2025-02-28
000341728 372__ $$aHORIZON-EIC-2022-ACCELERATOR-01$$s2023-03-01$$t2025-02-28
000341728 450__ $$aalphadbs$$wd$$y2023-03-01 - 2025-02-28
000341728 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000341728 680__ $$aDifferently from other DBS systems on the market, the AlphaDBS can be programmed with two different types of stimulation: conventional DBS, which is implemented also by other DBS systems, and adaptive DBS (aDBS) that automatically adjusts the energy delivered to patient using a biosignal, local field potential (LFP), in a close loop configuration. LFPs represent the synchronous presynaptic and postsynaptic activity of neuronal populations and can be recorded with the macro-electrodes routinely implanted for cDBS. In Parkinson Disease, LFPs (especially in beta-band) are specifically modulated by dopamine intake, movement execution and preparation, and that they encode non-motor functions, such as decision making. The beta band power represents the input variable to the adaptive algorithm, implemented by the AlphaDBS system, which, every second computes a new stimulation value.
000341728 909CO $$ooai:juser.fz-juelich.de:1011087$$pauthority:GRANT$$pauthority
000341728 909CO $$ooai:juser.fz-juelich.de:1011087
000341728 980__ $$aG
000341728 980__ $$aCORDIS
000341728 980__ $$aAUTHORITY