Record #342802 - GSI Repository

ENCHFATCS

Enantioselective N-α C(sp3)-H Functionalization of Amides by Trifunctional Catalytic Systems

Grant period	2023-08-01 - 2025-07-31
Funding body	European Union
Call number	HORIZON-MSCA-2022-PF-01
Grant number	101103744
Identifier	G:(EU-Grant)101103744

Note: The trifunctional catalytic systems (TCS) consisting of bifunctional photocatalysts and transition metals will be designed to achieve the enantioselective N-α C(sp3)-H functionalization of amides (ENCHFA). Mechanistically, the bifunctional chiral hydrogen bonding-based aryl ketones will activate the amides to form α-amido radicals via HAT and control their reactivity in an enantioselective manner while transition metal will provide another opportunity to active substrates and accomplish the photocatalytic cycle via a radical relay. Combining chiral hydrogen bonding-based aryl ketones with Co catalysis, the protocol will develop the external oxidant-free enantioselective N-α C-H alkenylation, arylation and alkoxylation of amides with H2 evolution. Furthermore, the enantioselective N-α C-H trifluoromethylation of amides will be relized by merging chiral hydrogen bonding-based aryl ketones with Cu catalysis. The trifunctional catalytic systems will not only enrich the types of enantioselective C-H functionalization of amides, but also reveal the mechanism of trifunctional catalytic systems, as well as provide guidance for designing multiple systems in asymmetric catalysis.

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Record created 2023-08-27, last modified 2023-08-27

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