000343141 001__ 343141
000343141 005__ 20230827173415.0
000343141 0247_ $$2CORDIS$$aG:(EU-Grant)101106871$$d101106871
000343141 0247_ $$2CORDIS$$aG:(EU-Call)HORIZON-MSCA-2022-PF-01$$dHORIZON-MSCA-2022-PF-01
000343141 0247_ $$2originalID$$acorda_____he::101106871
000343141 035__ $$aG:(EU-Grant)101106871
000343141 150__ $$aDruggability of G-quadruplexes, promising modulators for antimicrobial resistance$$y2023-09-01 - 2025-08-31
000343141 372__ $$aHORIZON-MSCA-2022-PF-01$$s2023-09-01$$t2025-08-31
000343141 450__ $$aThe G-Q-reat ESKAPE$$wd$$y2023-09-01 - 2025-08-31
000343141 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000343141 680__ $$aThe antimicrobial resistance (AMR) is an underrated problem promoted by widespread misuse and massive use of antibiotics. Thus, the health systems are facing enormous costs to treat nosocomial infections due to AMR bacteria. In particular, six highly virulent bacteria (E.S.K.A.P.E.) are the main responsible for worldwide nosocomial infections. In the last years, our research strategies to discover and develop new clinically relevant antibiotics lacked effectiveness. As a result, we are unable to efficiently treat AMR infections and are unprepared to face an AMR bacteria outbreak. One possible strategy is to target bacteria G-quadruplexes (bGQs) which are highly conserved DNA/RNA secondary structures pivotal for bacteria duplication, transcription and translation. This strategy is particular effective because, when a new pathogen emerges, its DNA/RNA genome is first disclosed through sequencing, hence the ability of quickly designing new drug candidates based only on this information will be a powerful tool to face a new epidemic/pandemic. Furthermore, the human GQs (hGQs) were largely investigated as possible target for anticancer treatment thus the interest in bGQs raised later and with less intensity than hGQs. In addition, most GQs modulators bind G-quartets top by π-stacking interactions and the druggability of GQs loops/grooves was still not addressed. In this context, the multidisciplinary of G-Q-reat ESKAPE project aims to provide a novel and effective strategy to contrast AMR by targeting bGQs and to expand the knowledge on bGQs.
000343141 909CO $$ooai:juser.fz-juelich.de:1012501$$pauthority:GRANT$$pauthority
000343141 909CO $$ooai:juser.fz-juelich.de:1012501
000343141 980__ $$aG
000343141 980__ $$aCORDIS
000343141 980__ $$aAUTHORITY