Record #344165 - GSI Repository

Sarcura

Cell Factory on chips: make Cell Therapies affordable and accessible to all patients

Grant period	2023-06-01 - 2024-05-31
Funding body	European Union
Call number	HORIZON-EIE-2022-SCALEUP-02
Grant number	101114315
Identifier	G:(EU-Grant)101114315

Note: Sarcura GmbH, an Austrian deep-tech company founded in November 2019, will develop and market a machine platform for the industrial GMP manufacturing of personalised cell therapeutics, such as CAR-T therapies. We will contribute to scale the global cell therapy manufacturing capacity of these lifesaving treatments from currently thousands of doses per year to hundreds of thousands of doses, cost effective and safe for all patients. Sarcura envisions to transform existing manufacturing paradigms by using leading-edge semiconductor technologies (such as integrated photonics) embedded in microfluidic liquid processing systems to bring bioprocess control to cellular level. We believe that only by bringing together automation, integration (of additional functionality), miniaturization, and modularity we can achieve the required 100-fold increase in manufacturing capacity the cell therapy industry requires Our initial focus is the development of a GMP ready, fully automated, industrial cell isolation device for the manufacturing of cell therapies. The device will include all necessary processing steps to handle the typical starting material of clinical cell therapy as well as provide integrated process analytics and quality control such as cell count, viability, phenotype characterization and other analytics After launching the first single unit operation device for the Cell Isolation, further devices performing the Formulation, Gene Transfer and Expansion followed by an integrated end-to-end device will be developed. Finally, we aim to market an autonomous, self-optimising manufacturing system based on real-time manufacturing optimisation via AI driven (artificial intelligence) predictive process control. Our product offer will include (a) desktop instruments, (b) single-use microfluidic cartridges, and (c) software and algorithms.

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Record created 2023-08-27, last modified 2023-08-27

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