000344420 001__ 344420
000344420 005__ 20230827173500.0
000344420 0247_ $$2CORDIS$$aG:(EU-Grant)101088740$$d101088740
000344420 0247_ $$2CORDIS$$aG:(EU-Call)ERC-2022-COG$$dERC-2022-COG
000344420 0247_ $$2originalID$$acorda_____he::101088740
000344420 035__ $$aG:(EU-Grant)101088740
000344420 150__ $$aProviding Computational Insights into Cardiac Xenotransplantation$$y2024-01-01 - 2028-12-31
000344420 372__ $$aERC-2022-COG$$s2024-01-01$$t2028-12-31
000344420 450__ $$aXenoSim$$wd$$y2024-01-01 - 2028-12-31
000344420 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000344420 680__ $$aWe are at the dawn of a new age in medicine, marked by the first pig-to-human heart transplant. Xenotransplantation has long been a dream for clinicians and now, due to rapid progress in gene editing, is becoming a reality. To overcome immediate rejection, barriers of immunity and infection have to be overcome, however, achieving long-term success requires a deep understanding of the physiological and mechanical challenges introduced by the anatomically dissimilar xenotransplants. XENOSIM aims to address these challenges by providing fundamental clinical insights into the nascent field of cardiac xenotransplantation through the development and application of novel high-resolution, higher-order, multiphysics simulation methods. Tremendous progress has been made in biomedical imaging, nonetheless, a multitude of physical phenomena relevant to xenotransplantation are not available for experimental observation. In silico studies are uniquely placed to provide insights into the haemodynamic disruption caused by replacing a human heart with an anatomically dissimilar one. XENOSIM is targeting the establishment of the first family of porcine cardiac xenotransplant models that can provide clinically significant insights into the haemodynamic compatibility of porcine donor hearts, the impact of surgical approach, and the consequence of pathologies. To provide these novel insights requires new coupled simulation approaches. Accordingly, the second goal of XENOSIM is to create a new class of monolithic finite volume fluid-electro-solid interaction methods, which can provide predictions in clinically relevant timescales through the exploitation of hybrid CPU-GPU systems. XENOSIM will establish the new field of computational cardiac xenotransplantation. Furthermore, the novel numerical methods established by XENOSIM are expected to impact a broad range of fields well beyond the project end.
000344420 909CO $$ooai:juser.fz-juelich.de:1013780$$pauthority:GRANT$$pauthority
000344420 909CO $$ooai:juser.fz-juelich.de:1013780
000344420 980__ $$aG
000344420 980__ $$aCORDIS
000344420 980__ $$aAUTHORITY