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000351423 1001_ $$0P:(DE-HGF)0$$aGlowa, Christin$$b0
000351423 245__ $$aRelative biological effectiveness of oxygen ion beams in the rat spinal cord: Dependence on linear energy transfer and dose and comparison with model predictions
000351423 260__ $$aAmsterdam [u. a.]$$bElsevier Science$$c2024
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000351423 520__ $$aIon beams exhibit an increased relative biological effectiveness (RBE) with respect to photons. This study determined the RBE of oxygen ion beams as a function of linear energy transfer (LET) and dose in the rat spinal cord.The spinal cord of rats was irradiated at four different positions of a 6 cm spread-out Bragg-peak (LET: 26, 66, 98 and 141 keV/µm) using increasing levels of single and split oxygen ion doses. Dose-response curves were established for the endpoint paresis grade II and based on ED50 (dose at 50 % effect probability), the RBE was determined and compared to model predictions.When LET increased from 26 to 98 keV/µm, ED50 decreased from 17.2 ± 0.3 Gy to 13.5 ± 0.4 Gy for single and from 21.7 ± 0.4 Gy to 15.5 ± 0.5 Gy for split doses, however, at 141 keV/µm, ED50 rose again to 15.8 ± 0.4 Gy and 17.2 ± 0.4 Gy, respectively. As a result, the RBE increased from 1.43 ± 0.05 to 1.82 ± 0.08 (single dose) and from 1.58 ± 0.04 to 2.21 ± 0.08 (split dose), respectively, before declining again to 1.56 ± 0.06 for single and 1.99 ± 0.06 for split doses at the highest LET. Deviations from RBE-predictions were model-dependent.This study established first RBE data for the late reacting central nervous system after single and split doses of oxygen ions. The data was used to validate the RBE-dependence on LET and dose of three RBE-models. This study extends the existing data base for protons, helium and carbon ions and provides important information for future patient treatments with oxygen ions.
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000351423 650_7 $$2Other$$aLate normal tissue effects
000351423 650_7 $$2Other$$aLinear energy transfer (LET)
000351423 650_7 $$2Other$$aLocal effect model (LEM)
000351423 650_7 $$2Other$$aModified microdosimetric kinetic model (mMKM)
000351423 650_7 $$2Other$$aMyelopathy
000351423 650_7 $$2Other$$aOxygen ion radiotherapy
000351423 650_7 $$2Other$$aRat spinal cord
000351423 650_7 $$2Other$$aRelative biological effectiveness (RBE)
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000351423 7001_ $$0P:(DE-HGF)0$$aSaager, Maria$$b1
000351423 7001_ $$0P:(DE-HGF)0$$aHintz, Lisa$$b2
000351423 7001_ $$0P:(DE-HGF)0$$aEuler-Lange, Rosemarie$$b3
000351423 7001_ $$0P:(DE-HGF)0$$aPeschke, Peter$$b4
000351423 7001_ $$0P:(DE-HGF)0$$aBrons, Stephan$$b5
000351423 7001_ $$0P:(DE-Ds200)OR1138$$aScholz, Michael$$b6$$ugsi
000351423 7001_ $$0P:(DE-HGF)0$$aMein, Stewart$$b7
000351423 7001_ $$0P:(DE-HGF)0$$aMairani, Andrea$$b8
000351423 7001_ $$0P:(DE-HGF)0$$aKarger, Christian P.$$b9$$eCorresponding author
000351423 773__ $$0PERI:(DE-600)2963795-8$$a10.1016/j.phro.2024.100581$$gVol. 30, p. 100581 -$$p100581$$tPhysics & Imaging in Radiation Oncology$$v30$$x2405-6316$$y2024
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