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@ARTICLE{Glowa:351423,
      author       = {Glowa, Christin and Saager, Maria and Hintz, Lisa and
                      Euler-Lange, Rosemarie and Peschke, Peter and Brons, Stephan
                      and Scholz, Michael and Mein, Stewart and Mairani, Andrea
                      and Karger, Christian P.},
      title        = {{R}elative biological effectiveness of oxygen ion beams in
                      the rat spinal cord: {D}ependence on linear energy transfer
                      and dose and comparison with model predictions},
      journal      = {Physics $\&$ Imaging in Radiation Oncology},
      volume       = {30},
      issn         = {2405-6316},
      address      = {Amsterdam [u. a.]},
      publisher    = {Elsevier Science},
      reportid     = {GSI-2024-00630},
      pages        = {100581},
      year         = {2024},
      note         = {This is an open access article under the CC BY license
                      (http://creativecommons.org/licenses/by/4.0/).},
      abstract     = {Ion beams exhibit an increased relative biological
                      effectiveness (RBE) with respect to photons. This study
                      determined the RBE of oxygen ion beams as a function of
                      linear energy transfer (LET) and dose in the rat spinal
                      cord.The spinal cord of rats was irradiated at four
                      different positions of a 6 cm spread-out Bragg-peak (LET:
                      26, 66, 98 and 141 keV/µm) using increasing levels of
                      single and split oxygen ion doses. Dose-response curves were
                      established for the endpoint paresis grade II and based on
                      ED50 (dose at 50 $\%$ effect probability), the RBE was
                      determined and compared to model predictions.When LET
                      increased from 26 to 98 keV/µm, ED50 decreased from 17.2 ±
                      0.3 Gy to 13.5 ± 0.4 Gy for single and from 21.7 ± 0.4 Gy
                      to 15.5 ± 0.5 Gy for split doses, however, at 141 keV/µm,
                      ED50 rose again to 15.8 ± 0.4 Gy and 17.2 ± 0.4 Gy,
                      respectively. As a result, the RBE increased from 1.43 ±
                      0.05 to 1.82 ± 0.08 (single dose) and from 1.58 ± 0.04 to
                      2.21 ± 0.08 (split dose), respectively, before declining
                      again to 1.56 ± 0.06 for single and 1.99 ± 0.06 for split
                      doses at the highest LET. Deviations from RBE-predictions
                      were model-dependent.This study established first RBE data
                      for the late reacting central nervous system after single
                      and split doses of oxygen ions. The data was used to
                      validate the RBE-dependence on LET and dose of three
                      RBE-models. This study extends the existing data base for
                      protons, helium and carbon ions and provides important
                      information for future patient treatments with oxygen ions.},
      keywords     = {Late normal tissue effects (Other) / Linear energy transfer
                      (LET) (Other) / Local effect model (LEM) (Other) / Modified
                      microdosimetric kinetic model (mMKM) (Other) / Myelopathy
                      (Other) / Oxygen ion radiotherapy (Other) / Rat spinal cord
                      (Other) / Relative biological effectiveness (RBE) (Other)},
      cin          = {BIO / BIO@FAIR},
      ddc          = {610},
      cid          = {I:(DE-Ds200)BIO-20160831OR354 / I:(DE-Ds200)Coll-FAIR-BIO},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / SUC-GSI-Heidelberg - Strategic
                      university cooperation GSI-U Heidelberg (SUC-GSI-HE)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-Ds200)SUC-GSI-HE},
      experiment   = {$EXP:(DE-Ds200)no_experiment-20200803$},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.phro.2024.100581},
      url          = {https://repository.gsi.de/record/351423},
}