TY  - JOUR
AU  - Galeone, Cosimo
AU  - Steinsberger, Timo
AU  - Donetti, M.
AU  - Martire, Maria Chiara
AU  - Milian, F. M.
AU  - Sacchi, R.
AU  - Vignati, A.
AU  - Volz, Lennart
AU  - Durante, Marco
AU  - Giordanengo, S.
AU  - Graeff, Christian
TI  - Real-time delivered dose assessment in carbon ion therapy of moving targets
JO  - Physics in medicine and biology
VL  - 69
IS  - 20
SN  - 0031-9155
CY  - Bristol
PB  - IOP Publ.
M1  - GSI-2024-00807
SP  - 205001
PY  - 2024
N1  - Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence.Grants: European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant
AB  - Objective. Real-time adaptive particle therapy is being investigated as a means to maximize the treatment delivery accuracy. To react to dosimetric errors, a system for fast and reliable verification of the agreement between planned and delivered doses is essential. This study presents a clinically feasible, real-time 4D-dose reconstruction system, synchronized with the treatment delivery and motion of the patient, which can provide the necessary feedback on the quality of the delivery.Approach. A GPU-based analytical dose engine capable of millisecond dose calculation for carbon ion therapy has been developed and interfaced with the next generation of the dose delivery system (DDS) in use at Centro Nazionale di Adroterapia Oncologica (CNAO). The system receives the spot parameters and the motion information of the patient during the treatment and performs the reconstruction of the planned and delivered 4D-doses. After each iso-energy layer, the results are displayed on a graphical user interface by the end of the spill pause of the synchrotron, permitting verification against the reference dose. The framework has been verified experimentally at CNAO for a lung cancer case based on a virtual phantom 4DCT. The patient's motion was mimicked by a moving Ionization Chamber (IC) 2D-array.Mainresults. For the investigated static and 4D-optimized treatment delivery cases, real-time dose reconstruction was achieved with an average pencil beam dose calculation speed up to more than one order of magnitude smaller than the spot delivery. The reconstructed doses have been benchmarked against offline log-file based dose reconstruction with the TRiP98 treatment planning system, as well as QA measurements with the IC 2D-array, where an average gamma-index passing rate (3
KW  - Humans
KW  - Radiotherapy Dosage
KW  - Heavy Ion Radiotherapy: methods
KW  - Time Factors
KW  - Radiotherapy Planning, Computer-Assisted: methods
KW  - Movement
KW  - Radiation Dosage
KW  - Four-Dimensional Computed Tomography
KW  - Phantoms, Imaging
KW  - Lung Neoplasms: radiotherapy
KW  - Radiometry: methods
KW  - adaptive therapy (Other)
KW  - moving targets (Other)
KW  - particle therapy (Other)
KW  - real-time dose calculation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39299266
UR  - <Go to ISI:>//WOS:001322177000001
DO  - DOI:10.1088/1361-6560/ad7d59
UR  - https://repository.gsi.de/record/353200
ER  -