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@ARTICLE{Bender:357806,
      author       = {Bender, Tamara and Schickel, Esther and Schielke, Celine
                      and Debus, Jürgen and Grosshans, David R. and Durante,
                      Marco and Schröder, Insa Sigrid},
      title        = {{A}berrant choroid plexus formation drives the development
                      of treatment-related brain toxicity},
      journal      = {Communications biology},
      volume       = {8},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {GSI-2025-00460},
      pages        = {276},
      year         = {2025},
      note         = {This work was funded by US NIH Grant1RO1CA256848-01, and
                      German Federal Ministry of Education andResearch (BMBF)
                      Grant 02 NUK 049A and 02NUK081A. This article is licensed
                      under a Creative Commons Attribution 4.0 International
                      License,},
      abstract     = {Brain tumors are commonly treated with radiotherapy, but
                      the efficacy of the treatment is limited by its toxicity to
                      the normal tissue including post-irradiation contrast
                      enhanced lesions often linked to necrosis. The poorly
                      understood mechanisms behind such brain lesions were studied
                      using cerebral organoids. Here we show that irradiation of
                      such organoids leads to dose-dependent growth retardation
                      and formation of liquid-filled cavities but is not
                      correlated with necrosis. Instead, the radiation-induced
                      changes comprise of an enhancement of cortical hem markers,
                      altered neuroepithelial stem cell differentiation, and an
                      increase of ZO1+/AQP1+/CLDN3+-choroid plexus (CP)-like
                      structures accompanied by an upregulation of IGF2 mRNA,
                      known to be expressed in CP and cerebrospinal fluid. The
                      altered differentiation is attributed to changes in the
                      WNT/BMP signaling pathways. We conclude that aberrant CP
                      formation can be involved in radiation-induced brain lesions
                      providing additional strategies for possible
                      countermeasures.},
      keywords     = {Choroid Plexus: metabolism / Choroid Plexus: radiation
                      effects / Animals / Organoids: metabolism / Mice / Brain
                      Neoplasms: genetics / Brain Neoplasms: pathology / Brain
                      Neoplasms: metabolism / Brain: metabolism / Brain: radiation
                      effects / Brain: pathology / Humans / Cell Differentiation /
                      Wnt Signaling Pathway},
      cin          = {BIO},
      ddc          = {570},
      cid          = {I:(DE-Ds200)BIO-20160831OR354},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / SUC-GSI-Heidelberg - Strategic
                      university cooperation GSI-U Heidelberg (SUC-GSI-HE) /
                      SUC-GSI-Darmstadt - Strategic university cooperation GSI-TU
                      Darmstadt (SUC-GSI-DA)},
      pid          = {G:(DE-HGF)POF4-633 / G:(DE-Ds200)SUC-GSI-HE /
                      G:(DE-Ds200)SUC-GSI-DA},
      experiment   = {$EXP:(DE-Ds200)External_experiment-20200803$ /
                      $EXP:(DE-Ds200)Biophysics_no_LSRF/EXP-20200803$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39987290},
      UT           = {WOS:001446985200013},
      doi          = {10.1038/s42003-025-07736-2},
      url          = {https://repository.gsi.de/record/357806},
}