%0 Journal Article
%A Bertho, Annaïg
%A Graeff, Christian
%A Ortiz, Ramon
%A Giorgi, Maria
%A Schuy, Christoph
%A Juchaux, Marjorie
%A Gilbert, Cristèle
%A Espenon, Julie
%A Oppermann, Julius
%A Sokol, Olga
%A Tinganelli, Walter
%A Prezado, Yolanda
%T Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model
%J Scientific reports
%V 15
%N 1
%@ 2045-2322
%C [London]
%I Springer Nature
%M GSI-2025-00509
%P 7305
%D 2025
%Z This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
%X Despite remarkable advances, radiation therapy (RT) remains inefficient for some bulky tumors, radioresistant tumors, and certain pediatric tumors. Minibeam radiation therapy (MBRT) has emerged as a promising approach, reducing normal tissue toxicity while enhancing immune responses. Preclinical studies using X-rays and proton MBRT have demonstrated enhanced therapeutic index for aggressive tumor models. Combining MBRT's advantages of spatial dose fractionation with the physical and biological benefits of carbon ions could be a step further toward unleashing the full potential of MBRT. This study aims to perform the first in vivo study of local and systemic responses of a subcutaneous mouse osteosarcoma (metastatic) model to carbon MBRT (C-MBRT) versus conventional carbon ion therapy (CT). Irradiations were conducted at the GSI Helmholtz Centre in Germany using 180 MeV/u 12C ions beam. All irradiated animals received an average dose (20 Gy) and displayed a significant and similar tumor growth delay in addition to a decreased metastasis score compared to the non-irradiated group. In the C-MBRT group, 70
%K Animals
%K Osteosarcoma: radiotherapy
%K Osteosarcoma: pathology
%K Mice
%K Heavy Ion Radiotherapy: methods
%K Disease Models, Animal
%K Cell Line, Tumor
%K Bone Neoplasms: radiotherapy
%K Bone Neoplasms: pathology
%K Carbon
%K Tumor Burden: radiation effects
%K Carbon ions (Other)
%K Carbon minibeam radiation therapy (C-MBRT) (Other)
%K Carbon therapy (Other)
%K Minibeam radiation therapy (Other)
%K Osteosarcoma (Other)
%K Radioresistant tumor (Other)
%K Carbon (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40025099
%U <Go to ISI:>//WOS:001435489800024
%R 10.1038/s41598-025-91872-6
%U https://repository.gsi.de/record/358325