000358325 001__ 358325
000358325 005__ 20260304232652.0
000358325 0247_ $$2doi$$a10.1038/s41598-025-91872-6
000358325 0247_ $$2datacite_doi$$a10.15120/GSI-2025-00509
000358325 0247_ $$2altmetric$$aaltmetric:174936579
000358325 0247_ $$2pmid$$apmid:40025099
000358325 0247_ $$2WOS$$aWOS:001435489800024
000358325 037__ $$aGSI-2025-00509
000358325 041__ $$aEnglish
000358325 082__ $$a600
000358325 1001_ $$0P:(DE-HGF)0$$aBertho, Annaïg$$b0
000358325 245__ $$aCarbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model
000358325 260__ $$a[London]$$bSpringer Nature$$c2025
000358325 3367_ $$2DRIVER$$aarticle
000358325 3367_ $$2DataCite$$aOutput Types/Journal article
000358325 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1772638473_335184
000358325 3367_ $$2BibTeX$$aARTICLE
000358325 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000358325 3367_ $$00$$2EndNote$$aJournal Article
000358325 500__ $$aThis article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
000358325 520__ $$aDespite remarkable advances, radiation therapy (RT) remains inefficient for some bulky tumors, radioresistant tumors, and certain pediatric tumors. Minibeam radiation therapy (MBRT) has emerged as a promising approach, reducing normal tissue toxicity while enhancing immune responses. Preclinical studies using X-rays and proton MBRT have demonstrated enhanced therapeutic index for aggressive tumor models. Combining MBRT's advantages of spatial dose fractionation with the physical and biological benefits of carbon ions could be a step further toward unleashing the full potential of MBRT. This study aims to perform the first in vivo study of local and systemic responses of a subcutaneous mouse osteosarcoma (metastatic) model to carbon MBRT (C-MBRT) versus conventional carbon ion therapy (CT). Irradiations were conducted at the GSI Helmholtz Centre in Germany using 180 MeV/u 12C ions beam. All irradiated animals received an average dose (20 Gy) and displayed a significant and similar tumor growth delay in addition to a decreased metastasis score compared to the non-irradiated group. In the C-MBRT group, 70% of the tumor volume received the valley dose, which is a very low dose of 1.5 Gy. The remaining 30% of the tumor received the peak dose of 105 Gy, resulting in an average dose of 20 Gy. These results suggest that C-MBRT triggered distinct mechanisms from CT and encourage further investigations to confirm the potential of C-MBRT for efficient treatment of radioresistant tumors.
000358325 536__ $$0G:(DE-HGF)POF4-633$$a633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633)$$cPOF4-633$$fPOF IV$$x0
000358325 536__ $$0G:(Ds200)GSI-FAIR-Phase-0$$aFAIR Phase-0 - FAIR Phase-0 Research Program (GSI-FAIR-Phase-0)$$cGSI-FAIR-Phase-0$$x1
000358325 536__ $$0G:(EU-Grant)101008548$$aHITRIplus - Heavy Ion Therapy Research Integration plus (101008548)$$c101008548$$fH2020-INFRAIA-2020-1$$x2
000358325 536__ $$0G:(EU-Grant)817908$$aPROTONMBRT - Spatial fractionation of the dose in proton therapy: a novel therapeutic approach (817908)$$c817908$$fERC-2018-COG$$x3
000358325 588__ $$aDataset connected to CrossRef, Journals: repository.gsi.de
000358325 650_7 $$2Other$$aCarbon ions
000358325 650_7 $$2Other$$aCarbon minibeam radiation therapy (C-MBRT)
000358325 650_7 $$2Other$$aCarbon therapy
000358325 650_7 $$2Other$$aMinibeam radiation therapy
000358325 650_7 $$2Other$$aOsteosarcoma
000358325 650_7 $$2Other$$aRadioresistant tumor
000358325 650_7 $$07440-44-0$$2NLM Chemicals$$aCarbon
000358325 650_2 $$2MeSH$$aAnimals
000358325 650_2 $$2MeSH$$aOsteosarcoma: radiotherapy
000358325 650_2 $$2MeSH$$aOsteosarcoma: pathology
000358325 650_2 $$2MeSH$$aMice
000358325 650_2 $$2MeSH$$aHeavy Ion Radiotherapy: methods
000358325 650_2 $$2MeSH$$aDisease Models, Animal
000358325 650_2 $$2MeSH$$aCell Line, Tumor
000358325 650_2 $$2MeSH$$aBone Neoplasms: radiotherapy
000358325 650_2 $$2MeSH$$aBone Neoplasms: pathology
000358325 650_2 $$2MeSH$$aCarbon
000358325 650_2 $$2MeSH$$aTumor Burden: radiation effects
000358325 693__ $$0EXP:(DE-Ds200)SBio08_Prezado-20200803$$1EXP:(DE-Ds200)HTM-20200803$$5EXP:(DE-Ds200)SBio08_Prezado-20200803$$aHTM$$eSBio08_Prezado: Heavy Ion Spatial Fractionated Radiotherapy (POF3-315; HTM )$$x0
000358325 7001_ $$0P:(DE-Ds200)OR5177$$aGraeff, Christian$$b1$$ugsi
000358325 7001_ $$0P:(DE-HGF)0$$aOrtiz, Ramon$$b2
000358325 7001_ $$0P:(DE-HGF)0$$aGiorgi, Maria$$b3
000358325 7001_ $$0P:(DE-Ds200)OR2115$$aSchuy, Christoph$$b4$$ugsi
000358325 7001_ $$0P:(DE-HGF)0$$aJuchaux, Marjorie$$b5
000358325 7001_ $$0P:(DE-HGF)0$$aGilbert, Cristèle$$b6
000358325 7001_ $$0P:(DE-HGF)0$$aEspenon, Julie$$b7
000358325 7001_ $$0P:(DE-Ds200)OR7675$$aOppermann, Julius$$b8$$ugsi
000358325 7001_ $$0P:(DE-Ds200)OR7224$$aSokol, Olga$$b9$$ugsi
000358325 7001_ $$0P:(DE-Ds200)OR2924$$aTinganelli, Walter$$b10$$ugsi
000358325 7001_ $$0P:(DE-HGF)0$$aPrezado, Yolanda$$b11$$eCorresponding author
000358325 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-025-91872-6$$gVol. 15, no. 1, p. 7305$$n1$$p7305$$tScientific reports$$v15$$x2045-2322$$y2025
000358325 8564_ $$uhttps://repository.gsi.de/record/358325/files/s41598-025-91872-6.pdf$$yOpenAccess
000358325 8564_ $$uhttps://repository.gsi.de/record/358325/files/s41598-025-91872-6.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000358325 909CO $$ooai:repository.gsi.de:358325$$pVDB$$pdriver$$popen_access$$pdnbdelivery$$pec_fundedresources$$popenaire
000358325 9101_ $$0I:(DE-Ds200)20121206GSI$$6P:(DE-Ds200)OR5177$$aGSI Helmholtzzentrum für Schwerionenforschung GmbH$$b1$$kGSI
000358325 9101_ $$0I:(DE-Ds200)20121206GSI$$6P:(DE-Ds200)OR2115$$aGSI Helmholtzzentrum für Schwerionenforschung GmbH$$b4$$kGSI
000358325 9101_ $$0I:(DE-Ds200)20121206GSI$$6P:(DE-Ds200)OR7675$$aGSI Helmholtzzentrum für Schwerionenforschung GmbH$$b8$$kGSI
000358325 9101_ $$0I:(DE-Ds200)20121206GSI$$6P:(DE-Ds200)OR7224$$aGSI Helmholtzzentrum für Schwerionenforschung GmbH$$b9$$kGSI
000358325 9101_ $$0I:(DE-Ds200)20121206GSI$$6P:(DE-Ds200)OR2924$$aGSI Helmholtzzentrum für Schwerionenforschung GmbH$$b10$$kGSI
000358325 9131_ $$0G:(DE-HGF)POF4-633$$1G:(DE-HGF)POF4-630$$2G:(DE-HGF)POF4-600$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vLife Sciences – Building Blocks of Life: Structure and Function$$x0
000358325 9141_ $$y2025
000358325 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCI REP-UK : 2022$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-07-29T15:28:26Z
000358325 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-07-29T15:28:26Z
000358325 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000358325 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2024-12-18
000358325 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-18
000358325 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000358325 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-18
000358325 920__ $$lyes
000358325 9201_ $$0I:(DE-Ds200)BIO-20160831OR354$$kBIO$$lBiophysik$$x0
000358325 9201_ $$0I:(DE-Ds200)Coll-FAIR-BIO$$kBIO@FAIR$$lCollaboration FAIR: BIO$$x1
000358325 980__ $$ajournal
000358325 980__ $$aVDB
000358325 980__ $$aI:(DE-Ds200)BIO-20160831OR354
000358325 980__ $$aI:(DE-Ds200)Coll-FAIR-BIO
000358325 980__ $$aUNRESTRICTED
000358325 9801_ $$aFullTexts