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@ARTICLE{Bertho:358325,
      author       = {Bertho, Annaïg and Graeff, Christian and Ortiz, Ramon and
                      Giorgi, Maria and Schuy, Christoph and Juchaux, Marjorie and
                      Gilbert, Cristèle and Espenon, Julie and Oppermann, Julius
                      and Sokol, Olga and Tinganelli, Walter and Prezado, Yolanda},
      title        = {{C}arbon minibeam radiation therapy results in tumor growth
                      delay in an osteosarcoma murine model},
      journal      = {Scientific reports},
      volume       = {15},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {GSI-2025-00509},
      pages        = {7305},
      year         = {2025},
      note         = {This article is licensed under a Creative Commons
                      Attribution-NonCommercial-NoDerivatives 4.0 International
                      License},
      abstract     = {Despite remarkable advances, radiation therapy (RT) remains
                      inefficient for some bulky tumors, radioresistant tumors,
                      and certain pediatric tumors. Minibeam radiation therapy
                      (MBRT) has emerged as a promising approach, reducing normal
                      tissue toxicity while enhancing immune responses.
                      Preclinical studies using X-rays and proton MBRT have
                      demonstrated enhanced therapeutic index for aggressive tumor
                      models. Combining MBRT's advantages of spatial dose
                      fractionation with the physical and biological benefits of
                      carbon ions could be a step further toward unleashing the
                      full potential of MBRT. This study aims to perform the first
                      in vivo study of local and systemic responses of a
                      subcutaneous mouse osteosarcoma (metastatic) model to carbon
                      MBRT (C-MBRT) versus conventional carbon ion therapy (CT).
                      Irradiations were conducted at the GSI Helmholtz Centre in
                      Germany using 180 MeV/u 12C ions beam. All irradiated
                      animals received an average dose (20 Gy) and displayed a
                      significant and similar tumor growth delay in addition to a
                      decreased metastasis score compared to the non-irradiated
                      group. In the C-MBRT group, $70\%$ of the tumor volume
                      received the valley dose, which is a very low dose of 1.5
                      Gy. The remaining $30\%$ of the tumor received the peak dose
                      of 105 Gy, resulting in an average dose of 20 Gy. These
                      results suggest that C-MBRT triggered distinct mechanisms
                      from CT and encourage further investigations to confirm the
                      potential of C-MBRT for efficient treatment of
                      radioresistant tumors.},
      keywords     = {Animals / Osteosarcoma: radiotherapy / Osteosarcoma:
                      pathology / Mice / Heavy Ion Radiotherapy: methods / Disease
                      Models, Animal / Cell Line, Tumor / Bone Neoplasms:
                      radiotherapy / Bone Neoplasms: pathology / Carbon / Tumor
                      Burden: radiation effects / Carbon ions (Other) / Carbon
                      minibeam radiation therapy (C-MBRT) (Other) / Carbon therapy
                      (Other) / Minibeam radiation therapy (Other) / Osteosarcoma
                      (Other) / Radioresistant tumor (Other) / Carbon (NLM
                      Chemicals)},
      cin          = {BIO},
      ddc          = {600},
      cid          = {I:(DE-Ds200)BIO-20160831OR354},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / FAIR Phase-0 - FAIR Phase-0
                      Research Program (GSI-FAIR-Phase-0) / HITRIplus - Heavy Ion
                      Therapy Research Integration plus (101008548) / PROTONMBRT -
                      Spatial fractionation of the dose in proton therapy: a novel
                      therapeutic approach (817908)},
      pid          = {G:(DE-HGF)POF4-633 / G:(Ds200)GSI-FAIR-Phase-0 /
                      G:(EU-Grant)101008548 / G:(EU-Grant)817908},
      experiment   = {$EXP:(DE-Ds200)SBio08_Prezado-20200803$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40025099},
      UT           = {WOS:001435489800024},
      doi          = {10.1038/s41598-025-91872-6},
      url          = {https://repository.gsi.de/record/358325},
}