%0 Journal Article
%A Steinsberger, Timo
%A Nakas, Anestis
%A Vai, Alessandro
%A Molinelli, Silvia
%A Donetti, Marco
%A Pullia, Marco
%A Martire, Maria Chiara
%A Galeone, Cosimo
%A Ciocca, Mario
%A Pella, Andrea
%A Vitolo, Viviana
%A Barcellini, Amelia
%A Orlandi, Ester
%A Imparato, Sara
%A Volz, Lennart
%A Baroni, Guido
%A Paganelli, Chiara
%A Durante, Marco
%A Graeff, Christian
%T Evaluation of motion mitigation strategies for carbon ion therapy of abdominal tumors based on non-periodic imaging data
%J Physics in medicine and biology
%V 70
%N 6
%@ 0031-9155
%C Bristol
%I IOP Publ.
%M GSI-2025-01089
%P 065002
%D 2025
%Z Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence
%X Objective.To identify suitable combination strategies for treatment planning and beam delivery in scanned carbon ion therapy of moving tumors.Approach. Carbon ion treatment plans for five abdominal tumors were optimized on four-dimensional (4D) computed tomography (CT) data using the following approaches. 4DITV across all phases and within a gating window, single phase uniform dose, and an innovative 4D tracking internal target volume (ITV) strategy. Delivered single-fraction doses were calculated on time-resolved virtual CT images reconstructed from 2D cine-magnetic resonance imaging series, using a deformable image registration pipeline. Treatment plans were combined with various beam delivery techniques: three-dimensional (no motion mitigation), rescanning, gating, beam tracking, and multi-phase 4D delivery with and without residual tracking (MP4D and MP4DRT) to form in total 11 treatment modalities. Single fraction doses were accumulated to simulate a fractionated treatment.Main results. Breath-sampled treatments using the MP4D and MP4DRT delivery techniques were the only to achieveD95> 95
%K Heavy Ion Radiotherapy: methods
%K Humans
%K Abdominal Neoplasms: radiotherapy
%K Abdominal Neoplasms: diagnostic imaging
%K Abdominal Neoplasms: physiopathology
%K Radiotherapy Planning, Computer-Assisted: methods
%K Four-Dimensional Computed Tomography
%K Movement
%K Magnetic Resonance Imaging
%K 4DMRI (Other)
%K carbon-ion radiotherapy (Other)
%K motion mitigation (Other)
%K time-resolved MRI (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39978068
%U <Go to ISI:>//WOS:001436975900001
%R 10.1088/1361-6560/adb89b
%U https://repository.gsi.de/record/362216