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000362973 0247_ $$2doi$$a10.1088/1361-6560/ae0674
000362973 0247_ $$2ISSN$$a0031-9155
000362973 0247_ $$2ISSN$$a1361-6560
000362973 0247_ $$2datacite_doi$$a10.15120/GSI-2025-01216
000362973 037__ $$aGSI-2025-01216
000362973 041__ $$aEnglish
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000362973 1001_ $$0P:(DE-HGF)0$$aLovatti, Giulio$$b0$$eCorresponding author
000362973 245__ $$aExperimental assessment of novel PET detector components for online imaging of radioactive ion beams
000362973 260__ $$aBristol$$bIOP Publ.$$c2025
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000362973 500__ $$aOriginal Content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence.
000362973 520__ $$aObjective.This work aims to evaluate the ability of novel detector components to measure with submillimeter resolution in beam positron emission tomography (PET) signals produced by10C and11C radioactive ion beams stopped in PMMA targets and to validate a simulation toolkit for reproducing beam physics and PET detector responses within the framework of the biomedical applications of radioactive ion beam (BARB) project.Approach.The PET system response was assessed by visualizing the radioactive distributions of the beams stopped in tissue surrogate phantoms, and the capacity of the simulation toolkit was evaluated by comparing the experimental results with simulations, both for the depth-dose distribution and PET imaging.Main results.The detector assembly accurately visualized the PET signal with submillimeter resolution, achieving the objective of measuring the difference in the positron range between10C and11C. The simulation toolkit effectively reproduced the beam characteristics and detector responses, showing a high degree of agreement between the simulated and experimental PET profiles under different beam delivery conditions.Significance.These findings demonstrate the precision and reliability of the novel in-beam PET detector technology and simulation toolkit for small animals, establishing a solid foundation for the second phase of the BARB project, which involves preclinical irradiation of living mice.
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000362973 536__ $$0G:(Ds200)GSI-FAIR-Phase-0$$aFAIR Phase-0 - FAIR Phase-0 Research Program (GSI-FAIR-Phase-0)$$cGSI-FAIR-Phase-0$$x1
000362973 536__ $$0G:(EU-Grant)883425$$aBARB - Biomedical Applications of Radioactive ion Beams (883425)$$c883425$$fERC-2019-ADG$$x2
000362973 536__ $$0G:(DE-Ds200)SUC-GSI-DA$$aSUC-GSI-Darmstadt - Strategic university cooperation GSI-TU Darmstadt (SUC-GSI-DA)$$cSUC-GSI-DA$$x3
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000362973 650_7 $$2Other$$aradioactive beam
000362973 650_7 $$2Other$$arange verification
000362973 650_7 $$2Other$$asmall animal PET detector
000362973 650_2 $$2MeSH$$aPositron-Emission Tomography: instrumentation
000362973 650_2 $$2MeSH$$aPhantoms, Imaging
000362973 650_2 $$2MeSH$$aAnimals
000362973 693__ $$0EXP:(DE-Ds200)SBio08_Parodi-20200803$$1EXP:(DE-Ds200)FRS-HTM-20200803$$5EXP:(DE-Ds200)SBio08_Parodi-20200803$$aFRS-HTM$$eSBio08_Parodi: Radioactive Ion Beams@GSI (POF3-315; FRS-HTM)$$x0
000362973 7001_ $$0P:(DE-HGF)0$$aNitta, Munetaka$$b1
000362973 7001_ $$0P:(DE-HGF)0$$aEvangelista, Francesco$$b2
000362973 7001_ $$0P:(DE-Ds200)OR6522$$aBoscolo, Daria$$b3$$ugsi
000362973 7001_ $$0P:(DE-Ds200)OR7111$$aKostyleva, Daria$$b4$$ugsi
000362973 7001_ $$0P:(DE-HGF)0$$aJavad Safari, Mohammad$$b5
000362973 7001_ $$0P:(DE-HGF)0$$aDedes, George$$b6
000362973 7001_ $$0P:(DE-HGF)0$$aGianoli, Chiara$$b7
000362973 7001_ $$0P:(DE-HGF)0$$aFoglia, Beatrice$$b8
000362973 7001_ $$0P:(DE-HGF)0$$aPinto, Marco$$b9
000362973 7001_ $$0P:(DE-HGF)0$$aGyu Kang, Han$$b10
000362973 7001_ $$0P:(DE-Ds200)OR3217$$aPurushothaman, Sivaji$$b11$$ugsi
000362973 7001_ $$0P:(DE-Ds200)OR0414$$aHaettner, Emma$$b12$$ugsi
000362973 7001_ $$0P:(DE-Ds200)OR2115$$aSchuy, Christoph$$b13$$ugsi
000362973 7001_ $$0P:(DE-Ds200)OR5177$$aGraeff, Christian$$b14$$ugsi
000362973 7001_ $$0P:(DE-Ds200)OR2545$$aWeber, Ulrich$$b15$$ugsi
000362973 7001_ $$0P:(DE-Ds200)OR1098$$aScheidenberger, Christoph$$b16$$ugsi
000362973 7001_ $$0P:(DE-HGF)0$$aG Thirolf, Peter$$b17
000362973 7001_ $$0P:(DE-HGF)0$$aYamaya, Taiga$$b18
000362973 7001_ $$0P:(DE-Ds200)OR2413$$aDurante, Marco$$b19$$ugsi
000362973 7001_ $$0P:(DE-HGF)0$$aParodi, Katia$$b20
000362973 773__ $$0PERI:(DE-600)1473501-5$$a10.1088/1361-6560/ae0674$$gVol. 70, no. 19, p. 195008 -$$n19$$p195008$$tPhysics in medicine and biology$$v70$$x0031-9155$$y2025
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