TY  - JOUR
AU  - Lovatti, Giulio
AU  - Nitta, Munetaka
AU  - Evangelista, Francesco
AU  - Boscolo, Daria
AU  - Kostyleva, Daria
AU  - Javad Safari, Mohammad
AU  - Dedes, George
AU  - Gianoli, Chiara
AU  - Foglia, Beatrice
AU  - Pinto, Marco
AU  - Gyu Kang, Han
AU  - Purushothaman, Sivaji
AU  - Haettner, Emma
AU  - Schuy, Christoph
AU  - Graeff, Christian
AU  - Weber, Ulrich
AU  - Scheidenberger, Christoph
AU  - G Thirolf, Peter
AU  - Yamaya, Taiga
AU  - Durante, Marco
AU  - Parodi, Katia
TI  - Experimental assessment of novel PET detector components for online imaging of radioactive ion beams
JO  - Physics in medicine and biology
VL  - 70
IS  - 19
SN  - 0031-9155
CY  - Bristol
PB  - IOP Publ.
M1  - GSI-2025-01216
SP  - 195008
PY  - 2025
N1  - Original Content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence.
AB  - Objective.This work aims to evaluate the ability of novel detector components to measure with submillimeter resolution in beam positron emission tomography (PET) signals produced by10C and11C radioactive ion beams stopped in PMMA targets and to validate a simulation toolkit for reproducing beam physics and PET detector responses within the framework of the biomedical applications of radioactive ion beam (BARB) project.Approach.The PET system response was assessed by visualizing the radioactive distributions of the beams stopped in tissue surrogate phantoms, and the capacity of the simulation toolkit was evaluated by comparing the experimental results with simulations, both for the depth-dose distribution and PET imaging.Main results.The detector assembly accurately visualized the PET signal with submillimeter resolution, achieving the objective of measuring the difference in the positron range between10C and11C. The simulation toolkit effectively reproduced the beam characteristics and detector responses, showing a high degree of agreement between the simulated and experimental PET profiles under different beam delivery conditions.Significance.These findings demonstrate the precision and reliability of the novel in-beam PET detector technology and simulation toolkit for small animals, establishing a solid foundation for the second phase of the BARB project, which involves preclinical irradiation of living mice.
KW  - Positron-Emission Tomography: instrumentation
KW  - Phantoms, Imaging
KW  - Animals
KW  - radioactive beam (Other)
KW  - range verification (Other)
KW  - small animal PET detector (Other)
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1088/1361-6560/ae0674
UR  - https://repository.gsi.de/record/362973
ER  -