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@ARTICLE{Lovatti:362973,
      author       = {Lovatti, Giulio and Nitta, Munetaka and Evangelista,
                      Francesco and Boscolo, Daria and Kostyleva, Daria and Javad
                      Safari, Mohammad and Dedes, George and Gianoli, Chiara and
                      Foglia, Beatrice and Pinto, Marco and Gyu Kang, Han and
                      Purushothaman, Sivaji and Haettner, Emma and Schuy,
                      Christoph and Graeff, Christian and Weber, Ulrich and
                      Scheidenberger, Christoph and G Thirolf, Peter and Yamaya,
                      Taiga and Durante, Marco and Parodi, Katia},
      title        = {{E}xperimental assessment of novel {PET} detector
                      components for online imaging of radioactive ion beams},
      journal      = {Physics in medicine and biology},
      volume       = {70},
      number       = {19},
      issn         = {0031-9155},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {GSI-2025-01216},
      pages        = {195008},
      year         = {2025},
      note         = {Original Content from this work may be used under the terms
                      of the Creative Commons Attribution 4.0 licence.},
      abstract     = {Objective.This work aims to evaluate the ability of novel
                      detector components to measure with submillimeter resolution
                      in beam positron emission tomography (PET) signals produced
                      by10C and11C radioactive ion beams stopped in PMMA targets
                      and to validate a simulation toolkit for reproducing beam
                      physics and PET detector responses within the framework of
                      the biomedical applications of radioactive ion beam (BARB)
                      project.Approach.The PET system response was assessed by
                      visualizing the radioactive distributions of the beams
                      stopped in tissue surrogate phantoms, and the capacity of
                      the simulation toolkit was evaluated by comparing the
                      experimental results with simulations, both for the
                      depth-dose distribution and PET imaging.Main results.The
                      detector assembly accurately visualized the PET signal with
                      submillimeter resolution, achieving the objective of
                      measuring the difference in the positron range between10C
                      and11C. The simulation toolkit effectively reproduced the
                      beam characteristics and detector responses, showing a high
                      degree of agreement between the simulated and experimental
                      PET profiles under different beam delivery
                      conditions.Significance.These findings demonstrate the
                      precision and reliability of the novel in-beam PET detector
                      technology and simulation toolkit for small animals,
                      establishing a solid foundation for the second phase of the
                      BARB project, which involves preclinical irradiation of
                      living mice.},
      keywords     = {Positron-Emission Tomography: instrumentation / Phantoms,
                      Imaging / Animals / radioactive beam (Other) / range
                      verification (Other) / small animal PET detector (Other)},
      cin          = {BIO},
      ddc          = {530},
      cid          = {I:(DE-Ds200)BIO-20160831OR354},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633) / FAIR Phase-0 - FAIR Phase-0
                      Research Program (GSI-FAIR-Phase-0) / BARB - Biomedical
                      Applications of Radioactive ion Beams (883425) /
                      SUC-GSI-Darmstadt - Strategic university cooperation GSI-TU
                      Darmstadt (SUC-GSI-DA)},
      pid          = {G:(DE-HGF)POF4-633 / G:(Ds200)GSI-FAIR-Phase-0 /
                      G:(EU-Grant)883425 / G:(DE-Ds200)SUC-GSI-DA},
      experiment   = {$EXP:(DE-Ds200)SBio08_Parodi-20200803$},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1088/1361-6560/ae0674},
      url          = {https://repository.gsi.de/record/362973},
}