Gast ::
| Hauptseite > Publikationsdatenbank > Base-excision repair increases DNA double-strand break clustering within heavy-ion tracks and modulates repair at δ-electron-induced breaks > print |
| 001 | 364933 | ||
| 005 | 20260223232529.0 | ||
| 024 | 7 | _ | |a 10.1038/s41598-025-32823-z |2 doi |
| 024 | 7 | _ | |a 10.15120/GSI-2026-00302 |2 datacite_doi |
| 024 | 7 | _ | |a pmid:41513727 |2 pmid |
| 024 | 7 | _ | |a WOS:001660886800005 |2 WOS |
| 037 | _ | _ | |a GSI-2026-00302 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 600 |
| 100 | 1 | _ | |a Schwan, Laura |0 P:(DE-Ds200)OR9718 |b 0 |e First author |
| 245 | _ | _ | |a Base-excision repair increases DNA double-strand break clustering within heavy-ion tracks and modulates repair at δ-electron-induced breaks |
| 260 | _ | _ | |a [London] |c 2026 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1768823738_2950249 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a grant 50WB2014 and the European Space Agency, grant AO-2019-IBER_005. "This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/." |
| 520 | _ | _ | |a Space radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. These induce highly clustered DNA damage along their tracks, which is difficult to repair. If this damage is not repaired correctly, or not at all, mutations and possibly cancer can occur in the long term. δ-electrons induced by fast heavy ions lead to further DNA damage outside ion tracks, resembling that of sparsely-ionising radiation. Using inhibitors of the crucial base-excision repair factors OGG1 and APE1, we show that the repair of DNA base-lesions within heavy-ion tracks causes DNA double-strand breaks (DSBs), which increases difficult-to-repair in-track DSB clustering. We further found that DSBs induced by δ-electrons of fast heavy ions are more often decorated by the resection factor RPA, which suggests that they are more often repaired in a resection-dependent manner than X-ray-induced DSBs, despite their resemblance. Using γH2AX assays to assess DSB repair kinetics, we found that δ-electron-induced DSBs are repaired faster than those induced by X-rays in G1-phase cells, despite the fact that δ-electron-induced DSBs are frequently resected, which typically entails slower repair processes. These findings on δ-electron-induced DSBs imply that the quantity of clustered DSBs in irradiated cells affects the overall response of cells to DNA-damage. Based on our results on base-excision repair and the processing of δ-electron-induced DSBs, we conclude that the interplay between DNA-damage repair processes is a pivotal factor in the course of DNA repair and, consequently, genomic integrity. |
| 536 | _ | _ | |a 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) |0 G:(DE-HGF)POF4-633 |c POF4-633 |f POF IV |x 0 |
| 536 | _ | _ | |a FAIR Phase-0 - FAIR Phase-0 Research Program (GSI-FAIR-Phase-0) |0 G:(Ds200)GSI-FAIR-Phase-0 |c GSI-FAIR-Phase-0 |x 1 |
| 536 | _ | _ | |a SUC-GSI-Darmstadt - Strategic university cooperation GSI-TU Darmstadt (SUC-GSI-DA) |0 G:(DE-Ds200)SUC-GSI-DA |c SUC-GSI-DA |x 2 |
| 588 | _ | _ | |a Dataset connected to DataCite |
| 650 | _ | 7 | |a Clustered DNA-damage |2 Other |
| 650 | _ | 7 | |a DNA repair |2 Other |
| 650 | _ | 7 | |a DNA-end resection |2 Other |
| 650 | _ | 7 | |a Heavy ions |2 Other |
| 650 | _ | 7 | |a Space radiation |2 Other |
| 650 | _ | 7 | |a δ-electrons |2 Other |
| 650 | _ | 7 | |a DNA-(Apurinic or Apyrimidinic Site) Lyase |0 EC 4.2.99.18 |2 NLM Chemicals |
| 650 | _ | 7 | |a DNA Glycosylases |0 EC 3.2.2.- |2 NLM Chemicals |
| 650 | _ | 7 | |a APEX1 protein, human |0 EC 4.2.99.18 |2 NLM Chemicals |
| 650 | _ | 7 | |a oxoguanine glycosylase 1, human |0 EC 3.2.2.- |2 NLM Chemicals |
| 650 | _ | 7 | |a Histones |2 NLM Chemicals |
| 650 | _ | 2 | |a DNA Breaks, Double-Stranded: radiation effects |2 MeSH |
| 650 | _ | 2 | |a DNA Repair: radiation effects |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Electrons: adverse effects |2 MeSH |
| 650 | _ | 2 | |a Heavy Ions: adverse effects |2 MeSH |
| 650 | _ | 2 | |a DNA-(Apurinic or Apyrimidinic Site) Lyase: metabolism |2 MeSH |
| 650 | _ | 2 | |a DNA-(Apurinic or Apyrimidinic Site) Lyase: antagonists & inhibitors |2 MeSH |
| 650 | _ | 2 | |a DNA Glycosylases: metabolism |2 MeSH |
| 650 | _ | 2 | |a DNA Glycosylases: antagonists & inhibitors |2 MeSH |
| 650 | _ | 2 | |a Histones: metabolism |2 MeSH |
| 650 | _ | 2 | |a Excision Repair |2 MeSH |
| 693 | _ | _ | |a HTA |e SESA: ESA Experiments at SIS (POF4-633; HTA) |1 EXP:(DE-Ds200)HTA-20200803 |0 EXP:(DE-Ds200)SESA-20200803 |5 EXP:(DE-Ds200)SESA-20200803 |x 0 |
| 700 | 1 | _ | |a Averbeck, Nicole B. |0 P:(DE-Ds200)OR2525 |b 1 |e Corresponding author |u gsi |
| 700 | 1 | _ | |a Durante, Marco |0 P:(DE-Ds200)OR2413 |b 2 |u gsi |
| 700 | 1 | _ | |a Jakob, Burkhard |0 P:(DE-Ds200)OR0522 |b 3 |e Last author |u gsi |
| 773 | _ | _ | |a 10.1038/s41598-025-32823-z |g Vol. 16, no. 1, p. 1339 |0 PERI:(DE-600)2615211-3 |n 1 |p 1339 |t Scientific reports |v 16 |y 2026 |x 2045-2322 |
| 856 | 4 | _ | |y OpenAccess |u https://repository.gsi.de/record/364933/files/s41598-025-32823-z.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://repository.gsi.de/record/364933/files/s41598-025-32823-z.pdf?subformat=pdfa |
| 909 | C | O | |o oai:repository.gsi.de:364933 |p openaire |p open_access |p OpenAPC |p driver |p VDB |p openCost |p dnbdelivery |
| 910 | 1 | _ | |a GSI Helmholtzzentrum für Schwerionenforschung GmbH |0 I:(DE-Ds200)20121206GSI |k GSI |b 0 |6 P:(DE-Ds200)OR9718 |
| 910 | 1 | _ | |a GSI Helmholtzzentrum für Schwerionenforschung GmbH |0 I:(DE-Ds200)20121206GSI |k GSI |b 1 |6 P:(DE-Ds200)OR2525 |
| 910 | 1 | _ | |a GSI Helmholtzzentrum für Schwerionenforschung GmbH |0 I:(DE-Ds200)20121206GSI |k GSI |b 2 |6 P:(DE-Ds200)OR2413 |
| 910 | 1 | _ | |a GSI Helmholtzzentrum für Schwerionenforschung GmbH |0 I:(DE-Ds200)20121206GSI |k GSI |b 3 |6 P:(DE-Ds200)OR0522 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Materie |l Von Materie zu Materialien und Leben |1 G:(DE-HGF)POF4-630 |0 G:(DE-HGF)POF4-633 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-600 |4 G:(DE-HGF)POF |v Life Sciences – Building Blocks of Life: Structure and Function |x 0 |
| 914 | 1 | _ | |y 2026 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2024-12-18 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b SCI REP-UK : 2022 |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2024-07-29T15:28:26Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2024-07-29T15:28:26Z |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2024-12-18 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2024-12-18 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2024-12-18 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2024-12-18 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2024-12-18 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2024-12-18 |
| 915 | p | c | |a APC keys set |2 APC |0 PC:(DE-HGF)0000 |
| 915 | p | c | |a Local Funding |2 APC |0 PC:(DE-HGF)0001 |
| 915 | p | c | |a DFG OA Publikationskosten |2 APC |0 PC:(DE-HGF)0002 |
| 915 | p | c | |a DEAL: Springer Nature 01.01.2024 |2 APC |0 PC:(DE-HGF)0178 |
| 915 | p | c | |a DOAJ Journal |2 APC |0 PC:(DE-HGF)0003 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Ds200)BIO-20160831OR354 |k BIO |l Biophysik |x 0 |
| 980 | 1 | _ | |a FullTexts |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Ds200)BIO-20160831OR354 |
| 980 | _ | _ | |a APC |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|