Journal Article

GSI-2024-00600

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview

Seane, E. N. (Corresponding author)Extern* ; Nair, S. ; Vandevoorde, C.GSI* ; Joubert, A.

2024
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/ph17050602  doi:10.15120/GSI-2024-00600

Abstract: Histone deacetylases inhibitors (HDACis) have shown promising therapeutic outcomes in haematological malignancies such as leukaemia, multiple myeloma, and lymphoma, with disappointing results in solid tumours when used as monotherapy. As a result, combination therapies either with radiation or other deoxyribonucleic acid (DNA) damaging agents have been suggested as ideal strategy to improve their efficacy in solid tumours. Numerous in vitro and in vivo studies have demonstrated that HDACis can sensitise malignant cells to both electromagnetic and particle types of radiation by inhibiting DNA damage repair. Although the radiosensitising ability of HDACis has been reported as early as the 1990s, the mechanisms of radiosensitisation are yet to be fully understood. This review brings forth the various protocols used to sequence the administration of radiation and HDACi treatments in the different studies. The possible contribution of these various protocols to the ambiguity that surrounds the mechanisms of radiosensitisation is also highlighted.

Keyword(s): DNA repair ; double strand break ; heterochromatin ; histone deacetylase inhibitors ; radiosensitisation

Note: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Contributing Institute(s):

1. Biophysik (BIO)
2. Collaboration FAIR: BIO (BIO@FAIR)

Research Program(s):

1. 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) (POF4-633)

Experiment(s):

1. no experiment theory work (theory)

Appears in the scientific report 2024

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