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@ARTICLE{Seane:350853,
      author       = {Seane, Elsie Neo and Nair, Shankari and Vandevoorde,
                      Charlot and Joubert, Anna},
      title        = {{M}echanistic {S}equence of {H}istone {D}eacetylase
                      {I}nhibitors and {R}adiation {T}reatment: {A}n {O}verview},
      journal      = {Pharmaceuticals},
      volume       = {17},
      number       = {5},
      issn         = {1424-8247},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {GSI-2024-00600},
      pages        = {602},
      year         = {2024},
      note         = {This article is an open access article distributed under
                      the terms and conditions of the Creative Commons Attribution
                      (CC BY) license
                      (https://creativecommons.org/licenses/by/4.0/).},
      abstract     = {Histone deacetylases inhibitors (HDACis) have shown
                      promising therapeutic outcomes in haematological
                      malignancies such as leukaemia, multiple myeloma, and
                      lymphoma, with disappointing results in solid tumours when
                      used as monotherapy. As a result, combination therapies
                      either with radiation or other deoxyribonucleic acid (DNA)
                      damaging agents have been suggested as ideal strategy to
                      improve their efficacy in solid tumours. Numerous in vitro
                      and in vivo studies have demonstrated that HDACis can
                      sensitise malignant cells to both electromagnetic and
                      particle types of radiation by inhibiting DNA damage repair.
                      Although the radiosensitising ability of HDACis has been
                      reported as early as the 1990s, the mechanisms of
                      radiosensitisation are yet to be fully understood. This
                      review brings forth the various protocols used to sequence
                      the administration of radiation and HDACi treatments in the
                      different studies. The possible contribution of these
                      various protocols to the ambiguity that surrounds the
                      mechanisms of radiosensitisation is also highlighted.},
      keywords     = {DNA repair (Other) / double strand break (Other) /
                      heterochromatin (Other) / histone deacetylase inhibitors
                      (Other) / radiosensitisation (Other)},
      cin          = {BIO / BIO@FAIR},
      ddc          = {610},
      cid          = {I:(DE-Ds200)BIO-20160831OR354 / I:(DE-Ds200)Coll-FAIR-BIO},
      pnm          = {633 - Life Sciences – Building Blocks of Life: Structure
                      and Function (POF4-633)},
      pid          = {G:(DE-HGF)POF4-633},
      experiment   = {$EXP:(DE-Ds200)no_experiment-20200803$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38794172},
      UT           = {WOS:001231544000001},
      doi          = {10.3390/ph17050602},
      url          = {https://repository.gsi.de/record/350853},
}