HITRIplus

Heavy Ion Therapy Research Integration plus

Grant period2021-04-01 - 2025-09-30
Funding bodyEuropean Union
Call numberH2020-INFRAIA-2020-1
Grant number101008548
IdentifierG:(EU-Grant)101008548

Note: The goal of Heavy Ion Therapy Research Integration plus (HITRIplus) is to integrate and propel biophysics and medical research on cancer treatment with heavy ions beams while jointly developing its sophisticated instruments. Cancer is a central health problem for our society. Heavy ion beams irradiate tumours by focussing on the ill tissue while sparing the healthy part around, more effectively than any other irradiation treatment. The wider objective of HITRIplus is to provide radiation oncologists with a cutting-edge tool to treat the fraction of tumours that are not curable with X-rays or protons or have better survival rates or lower recurrences with ions. For this major initiative, HITRIplus has gathered a consortium engaging all relevant stakeholders and for the first time bringing together all four European ion therapy centres with leading EU industries, academia, and research laboratories. They all share the ambition to jointly build a strong pan-European Heavy Ion Therapy Research Community. A strategic partner is the South East European International Institute for Sustainable Technologies, which federates eight countries in South East Europe with the ambition to build a next generation heavy ion Research Infrastructure in the area, to boost research and cooperation in a region trying to rebuild after a troubled past. HITRIplus Transnational Access will integrate and open to external researchers the experimental programme of the five European facilities providing therapeutic ion beams. Its Networks will structure and foster the research on heavy ion therapy, including clinical and pre-clinical research. Joint Research Activities will develop new accelerator and beam delivery technologies to extend the reach of the present generation centres and to define a new European reference design, at lower cost and dimensions, to make cancer ion therapy more accessible and to open new markets to European industry.
   

Recent Publications

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A generative adversarial network to improve integrated mode proton imaging resolution using paired proton–carbon data
Medical physics 52(9), e18081 () [10.1002/mp.18081] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Accelerator technologies for proton and ion beam therapy
Nature physics 21(9), 1363 - 1373 () [10.1038/s41567-025-02994-7] BibTeX | EndNote: XML, Text | RIS

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Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system
Zeitschrift für medizinische Physik 35(2), 218 - 226 () [10.1016/j.zemedi.2023.06.002] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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HyperSHArc: Single-Isocenter Stereotactic Radiosurgery of Multiple Brain Metastases Using Proton, Helium, and Carbon Ion Arc Therapy
Advances in radiation oncology 10(5), 101763 () [10.1016/j.adro.2025.101763] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model
Scientific reports 15(1), 7305 () [10.1038/s41598-025-91872-6] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Imaging lung tumor motion using integrated‐mode proton radiography—A phantom study towards tumor tracking in proton radiotherapy
Medical physics 52(2), 1146 - 1158 () [10.1002/mp.17508] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Exploring energy selection methods for robust biologically optimized carbon ion arc for head&neck cancer patients
Health and Technology 14(5), 873 - 888 () [10.1007/s12553-024-00877-0] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Deep learning-based voxel sampling for particle therapy treatment planning
Physics in medicine and biology 69(15), 155014 () [10.1088/1361-6560/ad5bba] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Opportunities and challenges of upright patient positioning in radiotherapy
Physics in medicine and biology 69(18), 18TR02 () [10.1088/1361-6560/ad70ee] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Focus stacking single-event particle radiography for high spatial resolution images and 3D feature localization.
Physics in medicine and biology 69(2), 024001 () [10.1088/1361-6560/ad131a] OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

All known publications ...
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 Record created 2021-10-10, last modified 2023-08-27