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Induction of Cytoplasmic dsDNA and cGAS-STING Immune Signaling After Exposure of Breast Cancer Cells to X-ray or High-Energetic Carbon Ions
Totis, C. (First author)GSI* ; Averbeck, N. B.GSI* ; Jakob, B.GSI* ; Schork, M.GSI* ; Volpi, G.GSI* ; Hintze, D. F.GSI* ; Durante, M.GSI* ; Fournier, C.GSI* ; Helm, A. (Corresponding author)GSI*
2025
Elsevier
Amsterdam
Please use a persistent id in citations: doi:10.1016/j.adro.2025.101783 doi:10.15120/GSI-2025-00765
Note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Contributing Institute(s):
- Biophysik (BIO)
Research Program(s):
- 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) (POF4-633)
- FAIR Phase-0 - FAIR Phase-0 Research Program (GSI-FAIR-Phase-0) (GSI-FAIR-Phase-0)
- SUC-GSI-Darmstadt - Strategic university cooperation GSI-TU Darmstadt (SUC-GSI-DA) (SUC-GSI-DA)
- 50WB2014 - Molekulare Grundlagen der Krebsentstehung durch kosmische Strahlung (BMWK-50WB2014) (BMWK-50WB2014)
- 02NUK054A - Verbundprojekt VERCHROMT II: Erkennung, Verarbeitung und biologische Konsequenzen von Chromatinschäden nach Teilchenbestrahlung II, Teilprojekt A (BMBF-02NUK054A) (BMBF-02NUK054A)
- BMBF-02NUK050A - Genetische Risiken und entzündungshemmende Wirkung von dicht-ionisierender alpha-Strahlung - Teilprojekt A (BMBF-02NUK050A) (BMBF-02NUK050A)
Experiment(s):
- SBio_Jakob: Radiation-induced DNA damage responses in the context of LET, chromatin, and cell cycle (POF3-315; HTA)
- SBio_Fournier: Modulation of immune and inflammatory response by densely ionizing irradiation (POF3-315; HTA)
Appears in the scientific report
2025
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