Journal Article

GSI-2025-01216

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Experimental assessment of novel PET detector components for online imaging of radioactive ion beams

Lovatti, G. (Corresponding author) ; Nitta, M. ; Evangelista, F. ; Boscolo, D.GSI* ; Kostyleva, D.GSI* ; Javad Safari, M. ; Dedes, G. ; Gianoli, C. ; Foglia, B. ; Pinto, M. ; Gyu Kang, H. ; Purushothaman, S.GSI* ; Haettner, E.GSI* ; Schuy, C.GSI* ; Graeff, C.GSI* ; Weber, U.GSI* ; Scheidenberger, C.GSI* ; G Thirolf, P. ; Yamaya, T. ; Durante, M.GSI* ; Parodi, K.

2025
IOP Publ. Bristol

Please use a persistent id in citations: doi:10.1088/1361-6560/ae0674  doi:10.15120/GSI-2025-01216

Abstract: Objective.This work aims to evaluate the ability of novel detector components to measure with submillimeter resolution in beam positron emission tomography (PET) signals produced by10C and11C radioactive ion beams stopped in PMMA targets and to validate a simulation toolkit for reproducing beam physics and PET detector responses within the framework of the biomedical applications of radioactive ion beam (BARB) project.Approach.The PET system response was assessed by visualizing the radioactive distributions of the beams stopped in tissue surrogate phantoms, and the capacity of the simulation toolkit was evaluated by comparing the experimental results with simulations, both for the depth-dose distribution and PET imaging.Main results.The detector assembly accurately visualized the PET signal with submillimeter resolution, achieving the objective of measuring the difference in the positron range between10C and11C. The simulation toolkit effectively reproduced the beam characteristics and detector responses, showing a high degree of agreement between the simulated and experimental PET profiles under different beam delivery conditions.Significance.These findings demonstrate the precision and reliability of the novel in-beam PET detector technology and simulation toolkit for small animals, establishing a solid foundation for the second phase of the BARB project, which involves preclinical irradiation of living mice.

Keyword(s): Positron-Emission Tomography: instrumentation (MeSH) ; Phantoms, Imaging (MeSH) ; Animals (MeSH) ; radioactive beam ; range verification ; small animal PET detector

Note: Original Content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence.

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Contributing Institute(s):

1. Biophysik (BIO)

Research Program(s):

1. 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) (POF4-633)
2. FAIR Phase-0 - FAIR Phase-0 Research Program (GSI-FAIR-Phase-0) (GSI-FAIR-Phase-0)
3. BARB - Biomedical Applications of Radioactive ion Beams (883425) (883425)
4. SUC-GSI-Darmstadt - Strategic university cooperation GSI-TU Darmstadt (SUC-GSI-DA) (SUC-GSI-DA)

Experiment(s):

1. SBio08_Parodi: Radioactive Ion Beams@GSI (POF3-315; FRS-HTM)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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